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Protein Page:
MFF (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MFF Plays a role in mitochondrial and peroxisomal fission. Belongs to the tango11 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 2q36.3
Cellular Component: mitochondrial outer membrane; peroxisome
Molecular Function: protein binding; protein homodimerization activity
Biological Process: mitochondrial fission; mitochondrial fragmentation during apoptosis; mitochondrial fusion; peroxisome fission; protein homooligomerization; protein targeting to mitochondrion; release of cytochrome c from mitochondria
Reference #:  Q9GZY8 (UniProtKB)
Alt. Names/Synonyms: C2orf33; DKFZp666J168; GL004; MFF; MGC110913; Mitochondrial fission factor
Gene Symbols: MFF
Molecular weight: 38,465 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Select Structure to View Below

MFF

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S157‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 6 S21‑p VSRAAFPsPTAAEMA
0 10 Y35‑p AEISRIQyEMEytEG
0 41 Y39‑p RIQyEMEytEGISQR
0 1 T40‑p IQyEMEytEGISQRM
0 1 K54‑ub MRVPEKLkVAPPNAD
1 2 S74‑p QEGVPNAsVIMQVPE
0 2 S93‑p AGNNEDVsFSRPADL
0 5 T106‑p DLDLIQStPFKPLAL
0 5 K109 LIQStPFKPLALKtP
0 2 K114 PFKPLALKtPPRVLt
0 25 T115‑p FKPLALKtPPRVLtL
0 4 T121‑p KtPPRVLtLsERPLD
0 3 S123‑p PPRVLtLsERPLDFL
0 15 T137‑p LDLERPPttPQNEEI
0 23 T138‑p DLERPPttPQNEEIR
0 1 N141 RPPttPQNEEIRAVG
1 124 S155‑p GRLKRERsMsENAVR
2 93 S157‑p LKRERsMsENAVRQN
1 50 S172‑p GQLVRNDsLWHRsDs
0 2 S177‑p NDsLWHRsDsAPRNK
0 2 S179‑p sLWHRsDsAPRNKIS
0 12 T200‑p SAPEYTVtPsPQQAR
0 17 S202‑p PEYTVtPsPQQARVC
0 3 S222‑p PEDGANLssARGILs
0 3 S223‑p EDGANLssARGILsL
0 3 S229‑p ssARGILsLIQsSTR
0 2 S233‑p GILsLIQsSTRRAYQ
0 7 S258‑p RPVLRGGsAAATsNP
0 1 S263‑p GGsAAATsNPHHDNV
0 1 Y272 PHHDNVRYGISNIDT
0 1 S275 DNVRYGISNIDTTIE
1 1 S285 DTTIEGTSDDLTVVD
0 1 T289 EGTSDDLTVVDAASL
0 1 S295 LTVVDAASLRRQIIK
1 0 K302 SLRRQIIKLNRRLQL
  MFF iso2  
- gap
Y9 AEISRIQYEMEYTEG
Y13 RIQYEMEYTEGISQR
T14 IQYEMEYTEGISQRM
K28 MRVPEKLKVAPPNAD
S48 QEGVPNASVIMQVPE
S67 AGNNEDVSFSRPADL
T80‑p DLDLIQStPFKPLAL
K83 LIQStPFKPLALKtP
K88 PFKPLALKtPPRVLT
T89‑p FKPLALKtPPRVLTL
T95 KtPPRVLTLSERPLD
S97 PPRVLTLSERPLDFL
T111 LDLERPPTTPQNEEI
T112 DLERPPTTPQNEEIR
N115 RPPTTPQNEEIRAVG
S129‑p GRLKRERsMsENAVR
S131‑p LKRERsMsENAVRQN
S146‑p GQLVRNDsLVtPsPQ
- gap
- gap
T149‑p VRNDsLVtPsPQQAR
S151‑p NDsLVtPsPQQARVC
S171 PEDGANLSSARGILS
S172 EDGANLSSARGILSL
S178 SSARGILSLIQSSTR
S182 GILSLIQSSTRRAYQ
S207 RPVLRGGSAAATSNP
S212 GGSAAATSNPHHDNV
Y221 PHHDNVRYGISNIDT
S224 DNVRYGISNIDTTIE
S234 DTTIEGTSDDLTVVD
T238 EGTSDDLTVVDAASL
S244 LTVVDAASLRRQIIk
K251‑ub SLRRQIIkLNRRLQL
49281 : Phospho-MFF (Ser146) Antibody
  MFF iso4  
- gap
Y9 AEISRIQYEMEYTEG
Y13 RIQYEMEYTEGISQR
T14 IQYEMEYTEGISQRM
K28 MRVPEKLKVAPPNAD
S48 QEGVPNASVIMQVPE
S67 AGNNEDVSFSRPADL
T80 DLDLIQSTPFKPLAL
K83 LIQSTPFKPLALKTP
K88 PFKPLALKTPPRVLT
T89 FKPLALKTPPRVLTL
T95 KTPPRVLTLSERPLD
S97 PPRVLTLSERPLDFL
T111 LDLERPPTTPQNEEI
T112 DLERPPTTPQNEEIR
N115 RPPTTPQNEEIRAVG
S129 GRLKRERSMSENAVR
S131 LKRERSMSENAVRQN
S146‑p GQLVRNDsLYGISNI
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y148 LVRNDsLYGISNIDT
S151 NDsLYGISNIDTTIE
S161 DTTIEGTSDDLTVVD
T165 EGTSDDLTVVDAASL
S171 LTVVDAASLRRQIIK
K178 SLRRQIIKLNRRLQL
49281 : Phospho-MFF (Ser146) Antibody
  MFF iso5  
- gap
Y9 AEISRIQYEMEYTEG
Y13 RIQYEMEYTEGISQR
T14 IQYEMEYTEGISQRM
K28 MRVPEKLKVAPPNAD
S48 QEGVPNASVIMQVPE
S67 AGNNEDVSFSRPADL
T80‑p DLDLIQStPFKPLAL
K83 LIQStPFKPLALKtP
K88 PFKPLALKtPPRVLT
T89‑p FKPLALKtPPRVLTL
T95 KtPPRVLTLSERPLD
S97 PPRVLTLSERPLDFL
T111 LDLERPPTTPQNEEI
T112 DLERPPTTPQNEEIR
N115 RPPTTPQNEEIRAVG
S129‑p GRLKRERsMsENAVR
S131‑p LKRERsMsENAVRQN
S146‑p GQLVRNDsLPVLRGG
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S154‑p LPVLRGGsAAATsNP
S159‑p GGsAAATsNPHHDNV
Y168 PHHDNVRYGISNIDT
S171 DNVRYGISNIDTTIE
S181 DTTIEGTSDDLTVVD
T185 EGTSDDLTVVDAASL
S191 LTVVDAASLRRQIIK
K198 SLRRQIIKLNRRLQL
49281 : Phospho-MFF (Ser146) Antibody
  mouse

► Hide Isoforms
 
- gap
Y9 AEISRIQYEMEYTEG
Y13 RIQYEMEYTEGISQR
T14 IQYEMEYTEGISQRM
K28 MRVPEKLKVAPPNAD
S48 QDGVPNASVIMQVPE
S67 TGNNEDISFSRPADL
T80‑p DLDLIQStPFkPLAL
K83‑ub LIQStPFkPLALKtP
K88 PFkPLALKtPPRVLT
T89‑p FkPLALKtPPRVLTL
T95 KtPPRVLTLSERPLD
S97 PPRVLTLSERPLDFL
P111 LDLERPLPtPQsEES
T112‑p DLERPLPtPQsEESR
S115‑p RPLPtPQsEESRAVG
S129‑p GRLKRERsMsENAVR
S131‑p LKRERsMsENAVRQN
S146‑p GQLVRNDsIVtPsPP
- gap
- gap
T149‑p VRNDsIVtPsPPQAR
S151‑p NDsIVtPsPPQARVC
S171 PEDGANLSSARGILs
S172 EDGANLSSARGILsL
S178‑p SSARGILsLIQSSTR
S182 GILsLIQSSTRRAYQ
S207‑p RPVLRGGsAAATSNP
S212 GGsAAATSNPHHDNV
Y221 PHHDNVRYGISNLDA
S224 DNVRYGISNLDAAIE
S234‑p DAAIEGAsDDMtVVD
T238‑p EGAsDDMtVVDAAsL
S244‑p MtVVDAAsLRRQIIK
K251 sLRRQIIKLNRRLQL
49281 : Phospho-MFF (Ser146) Antibody
  MFF iso2  
- gap
Y9 AEISRIQYEMEYTEG
Y13 RIQYEMEYTEGISQR
T14 IQYEMEYTEGISQRM
K28 MRVPEKLKVAPPNAD
S48 QDGVPNASVIMQVPE
S67 TGNNEDISFSRPADL
T80 DLDLIQSTPFKPLAL
K83 LIQSTPFKPLALKtP
K88 PFKPLALKtPPRVLT
T89‑p FKPLALKtPPRVLTL
T95 KtPPRVLTLSERPLD
S97 PPRVLTLSERPLDFL
P111 LDLERPLPtPQSEEQ
T112‑p DLERPLPtPQSEEQS
S115 RPLPtPQSEEQSRAV
S130 GRLKRERSMSENAVR
S132 LKRERSMSENAVRQN
S147‑p GQLVRNDsIPVLRGG
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S155 IPVLRGGSAAATSNP
S160 GGSAAATSNPHHDNV
Y169 PHHDNVRYGISNLDA
S172 DNVRYGISNLDAAIE
S182 DAAIEGASDDMTVVD
T186 EGASDDMTVVDAASL
S192 MTVVDAASLRRQIIK
K199 SLRRQIIKLNRRLQL
49281 : Phospho-MFF (Ser146) Antibody
  MFF iso4  
- gap
Y9 AEISRIQYEMEYTEG
Y13 RIQYEMEYTEGISQR
T14 IQYEMEYTEGISQRM
K28 MRVPEKLKVAPPNAD
S48‑p QDGVPNAsVIMQVPE
S67 TGNNEDISFSRPADL
T80 DLDLIQSTPFKPLAL
K83 LIQSTPFKPLALKTP
K88 PFKPLALKTPPRVLT
T89 FKPLALKTPPRVLTL
T95 KTPPRVLTLSERPLD
S97 PPRVLTLSERPLDFL
P111 LDLERPLPTPQSEES
T112 DLERPLPTPQSEESR
S115 RPLPTPQSEESRAVG
S129‑p GRLKRERsMsENAVR
S131‑p LKRERsMsENAVRQN
S146‑p GQLVRNDsMyGIsNL
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y148‑p LVRNDsMyGIsNLDA
S151‑p NDsMyGIsNLDAAIE
S161‑p DAAIEGAsDDMTVVD
T165 EGAsDDMTVVDAASL
S171 MTVVDAASLRRQIIK
K178 SLRRQIIKLNRRLQL
49281 : Phospho-MFF (Ser146) Antibody
  rat

 
S21‑p VSGAAFPsPTAAEMA
Y35 AEISRIQYEMEYTEG
Y39 RIQYEMEYTEGISQR
T40 IQYEMEYTEGISQRM
K54 MRVPEKLKVAPPNAD
S74 QDGVPNASVIMQVPE
S93 TGNNEDISFSRPADL
T106 DLDLIQSTPFkPLAL
K109‑ub LIQSTPFkPLALkTP
K114‑ub PFkPLALkTPPRVLT
T115 FkPLALkTPPRVLTL
T121 kTPPRVLTLSERPLD
S123 PPRVLTLSERPLDFL
P137 LDLERPPPTPQSEEI
T138 DLERPPPTPQSEEIR
S141 RPPPTPQSEEIRAVG
S155 GRLKRERSMsENAVR
S157‑p LKRERSMsENAVRQN
S172 GQLVRNDSMYGISSL
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y174 LVRNDSMYGISSLDA
S177 NDSMYGISSLDAAVE
S187 DAAVEGASEDMSVVD
S191 EGASEDMSVVDAASL
S197 MSVVDAASLRRQIIK
K204 SLRRQIIKLNRRLQL
49281 : Phospho-MFF (Ser146) Antibody
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