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Protein Page:
DRD2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DRD2 Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Defects in DRD2 are associated with dystonia type 11 (DYT11); also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: acrosome; axon; cytosol; dendrite; dendritic spine; endocytic vesicle; integral to plasma membrane; intracellular; lateral plasma membrane; nerve terminal; nonmotile primary cilium; perikaryon; plasma membrane; postsynaptic density; synaptic vesicle membrane
Molecular Function: adrenoceptor activity; dopamine binding; dopamine D2 receptor-like receptor activity; drug binding; identical protein binding; ionotropic glutamate receptor binding; potassium channel regulator activity; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: activation of protein kinase activity; adenohypophysis development; adult walking behavior; arachidonic acid secretion; associative learning; auditory behavior; axonogenesis; behavioral response to cocaine; behavioral response to ethanol; branching morphogenesis of a nerve; cellular calcium ion homeostasis; cerebral cortex GABAergic interneuron migration; circadian regulation of gene expression; dopamine metabolic process; dopamine receptor, adenylate cyclase inhibiting pathway; dopamine receptor, phospholipase C activating pathway; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior; G-protein coupled receptor internalization; grooming behavior; locomotory behavior; long-term memory; negative regulation of adenylate cyclase activity; negative regulation of blood pressure; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of circadian sleep/wake cycle, sleep; negative regulation of dopamine receptor signaling pathway; negative regulation of dopamine secretion; negative regulation of innate immune response; negative regulation of insulin secretion; negative regulation of protein kinase B signaling cascade; negative regulation of protein secretion; negative regulation of synaptic transmission, glutamatergic; nerve-nerve synaptic transmission; orbitofrontal cortex development; peristalsis; phosphatidylinositol metabolic process; pigmentation; positive regulation of cytokinesis; positive regulation of dopamine uptake; positive regulation of G-protein coupled receptor protein signaling pathway; positive regulation of growth hormone secretion; positive regulation of multicellular organism growth; positive regulation of neuroblast proliferation; positive regulation of receptor internalization; positive regulation of transcription from RNA polymerase II promoter; prepulse inhibition; protein localization; reduction of cytosolic calcium ion concentration; regulation of cAMP metabolic process; regulation of dopamine secretion; regulation of dopamine uptake; regulation of heart rate; regulation of long-term neuronal synaptic plasticity; regulation of phosphoprotein phosphatase activity; regulation of potassium ion transport; regulation of sodium ion transport; regulation of synapse structural plasticity; regulation of synaptic transmission, GABAergic; regulation of systemic arterial blood pressure by neurological process; release of sequestered calcium ion into cytosol; response to amphetamine; response to axon injury; response to cocaine; response to drug; response to hypoxia; response to inactivity; response to iron ion; response to light stimulus; response to morphine; response to nicotine; response to toxin; sensory perception of smell; striatum development; synaptic transmission, dopaminergic; synaptogenesis; thermoregulation; visual learning; Wnt receptor signaling pathway
Disease: Myoclonic Dystonia
Reference #:  P14416 (UniProtKB)
Alt. Names/Synonyms: D(2) dopamine receptor; D2DR; D2R; Dopamine D2 receptor; dopamine receptor D2; dopamine receptor D2 isoform; DRD2
Gene Symbols: DRD2
Molecular weight: 50,619 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Select Structure to View Below

DRD2

Protein Structure Not Found.
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Sites Implicated In
signaling pathway regulation: S321‑p
activity, inhibited: S354‑p
intracellular localization: S354‑p
molecular association, regulation: S354‑p
receptor desensitization, inhibited: S321‑p
receptor internalization, altered: T225‑p
receptor internalization, induced: S321‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
2 0 T134‑p AISIDRYtAVAMPML
1 0 T144‑p AMPMLYNtRYssKRR
1 0 S147‑p MLYNtRYssKRRVTV
1 0 S148‑p LYNtRYssKRRVTVM
2 0 T225‑p RRRKRVNtKRssRAF
2 0 S228‑p KRVNtKRssRAFRAH
2 0 S229‑p RVNtKRssRAFRAHL
1 0 K241 AHLRAPLKGNCTHPE
1 0 S321‑p GLHSTPDsPAkPEKN
0 1 K324‑m1 STPDsPAkPEKNGHA
0 1 K332‑m1 PEKNGHAkDHPkIAK
0 1 K336‑m1 GHAkDHPkIAKIFEI
2 0 S354‑p PNGKTRTsLKTMsRR
0 1 S359‑p RTsLKTMsRRKLSQQ
  DRD2 iso2  
T134‑p AISIDRYtAVAMPML
T144 AMPMLYNTRYSSKRR
S147 MLYNTRYSSKRRVTV
S148 LYNTRYSSKRRVTVM
T225‑p RRRKRVNtKRssRAF
S228‑p KRVNtKRssRAFRAH
S229‑p RVNtKRssRAFRAHL
K241 AHLRAPLKEAARRAQ
S292 GLHSTPDSPAKPEKN
K295 STPDSPAKPEKNGHA
K303 PEKNGHAKDHPKIAK
K307 GHAKDHPKIAKIFEI
S325‑p PNGKTRTsLKTMSRR
S330 RTsLKTMSRRKLSQQ
  mouse

 
T134 AISIDRYTAVAMPML
T144 AMPMLYNTRYSSKRR
S147 MLYNTRYSSKRRVTV
S148 LYNTRYSSKRRVTVM
T225 KRRKRVNTKRSSRAF
S228 KRVNTKRSSRAFRAN
S229 RVNTKRSSRAFRANL
K241 ANLKTPLKGNCTHPE
S321 GLHSNPDSPAKPEKN
K324 SNPDSPAKPEKNGHA
K332 PEKNGHAKIVNPRIA
R337 HAKIVNPRIAKFFEI
S355 PNGKTRTSLKTMSRR
S360 RTSLKTMSRRKLSQQ
  rat

 
T134 AISIDRYTAVAMPML
T144 AMPMLYNTRYSSKRR
S147 MLYNTRYSSKRRVTV
S148 LYNTRYSSKRRVTVM
T225 KRRKRVNTKRSSRAF
S228 KRVNTKRSSRAFRAN
S229 RVNTKRSSRAFRANL
K241‑ub ANLKTPLkGNCTHPE
S321 GLHSNPDSPAKPEKN
K324 SNPDSPAKPEKNGHA
K332 PEKNGHAKIVNPRIA
R337 HAKIVNPRIAKFFEI
S355 PNGKTRTSLKTMSRR
S360 RTSLKTMSRRKLSQQ
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