a protein kinase of the MAPK family. Plays a critical role in the regulation of cell growth and differentiation. Localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. Note: This description may include information from UniProtKB.
Protein type: EC 184.108.40.206; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily
Cellular Component: cytoplasm; nucleus; protein complex
Molecular Function: MAP kinase activity; protein binding; protein heterodimerization activity; protein kinase activity; protein kinase binding
Biological Process: protein amino acid phosphorylation
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.