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Protein Page:
ERK3 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ERK3 a protein kinase of the MAPK family. Plays a critical role in the regulation of cell growth and differentiation. Localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CMGC; EC 2.7.11.24; CMGC group; MAPK family; ERK subfamily; MAPK/ERK subfamily
Cellular Component: cytoplasm; nucleus; protein complex
Molecular Function: MAP kinase activity; protein binding; protein heterodimerization activity; protein kinase activity; protein kinase binding
Biological Process: protein amino acid phosphorylation
Reference #:  Q61532 (UniProtKB)
Alt. Names/Synonyms: 2610021I23Rik; D130053K17Rik; ERK-3; Erk-3 related; Erk3; Extracellular signal-regulated kinase 3; MAP kinase 6; MAPK 6; Mapk4; Mapk6; Mapk63; mitogen activated protein kinase 4; mitogen activated protein kinase 6; Mitogen-activated protein kinase 6; MK06; Prkm4; Prkm6; protein kinase, mitogen activated kinase 4
Gene Symbols: Mapk6
Molecular weight: 82,199 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ERK3

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K4 ____MAEKFESLMNI
0 1 T54 AIKKIVLTDPQSVKH
0 1 S145 RGLKYIHSANVLHRD
0 1 K154 NVLHRDLKPANLFIN
0 1 Y182 ARIMDPHYSHKGHLs
5 27 S189‑p YSHKGHLsEGLVTKW
0 1 Y209 LLLSPNNYTKAIDMW
0 1 R276 NDMTEPHRPLTQLLP
0 1 Y357 HIYNWERYHDCQFsE
0 16 S363‑p RYHDCQFsEHDWPIH
1 18 S386‑p QLDPRALsDVtDEEE
0 17 T389‑p PRALsDVtDEEEVQV
0 1 S441‑p KYCDLECsHTCNYKT
0 1 K447 CsHTCNYKTRSSPYL
0 1 S450 TCNYKTRSSPYLDNL
0 4 P452 NYKTRSSPYLDNLVW
0 1 Y453 YKTRSSPYLDNLVWR
0 5 Y467 RESEVNHYYEPKLII
0 1 Y468 ESEVNHYYEPKLIID
0 1 K471 VNHYYEPKLIIDLSN
0 3 K480 IIDLSNWKEQsKEKS
0 2 S483‑p LSNWKEQsKEKSDKR
0 1 K502 CERNGLVKAQIALEE
0 1 S511 QIALEEASQQLAERE
0 2 - gap
0 3 S554‑p KLNDLNSsVSQLELK
0 1 S556 NDLNSsVSQLELKSL
0 2 K561 sVSQLELKSLISKSV
0 1 K566 ELKSLISKSVSREKQ
0 2 K630 TYTSYLDKFFSRKED
0 1 K635 LDKFFSRKEDSEMLE
0 1 T643 EDSEMLETEPVEEGK
0 1 K650 TEPVEEGKRGERGRE
0 10 G664 EAGLLSGGGEFLLSK
1 9 S683‑p IGTPQFHsPVGsPLK
1 8 S687‑p QFHsPVGsPLKSIQA
1 1 T697 KSIQATLTPSAMKSs
0 1 S703 LTPSAMKSsPQIPHK
1 2 S704‑p TPSAMKSsPQIPHKT
  human

 
K4‑ub ____MAEkFESLMNI
T54‑p AIKKIVLtDPQSVKH
S145‑p RGLKYIHsANVLHRD
K154‑ub NVLHRDLkPANLFIN
Y182‑p ARIMDPHySHKGHLs
S189‑p ySHKGHLsEGLVTKW
Y209‑p LLLSPNNyTKAIDMW
K276‑ub NDMTEPHkPLTQLLP
Y357‑p HIYNWERyHDCQFsE
S363‑p RyHDCQFsEHDWPVH
S386‑p QLDPRALsDVtDEEE
T389‑p PRALsDVtDEEEVQV
S441 KYCDLECSHTCNYkT
K447‑ub CSHTCNYkTRsSsyL
S450‑p TCNYkTRsSsyLDNL
S452‑p NYkTRsSsyLDNLVW
Y453‑p YkTRsSsyLDNLVWR
Y467‑p RESEVNHyyEPkLII
Y468‑p ESEVNHyyEPkLIID
K471‑ub VNHyyEPkLIIDLSN
K480‑ub IIDLSNWkEQsKEKS
S483‑p LSNWkEQsKEKSDKK
K502‑ub CERNGLVkAQIALEE
S511‑p QIALEEAsQQLAGkE
K517‑ub AsQQLAGkEREKNQG
S556‑p KLNDLNSsVsQLELk
S558‑p NDLNSsVsQLELkSL
K563‑ub sVsQLELkSLISkSV
K568‑ub ELkSLISkSVSQEKQ
K631‑ub TYTSYLDkFFSRkED
K636‑ub LDkFFSRkEDTEMLE
T644‑p EDTEMLEtEPVEDGk
K651‑ub tEPVEDGkLGERGHE
S665‑p EEGFLNNsGEFLFNK
S684‑p IGIPQFHsPVGsPLK
S688‑p QFHsPVGsPLKSIQA
T698‑p KSIQATLtPSAMKss
S704‑p LtPSAMKssPQIPHQ
S705‑p tPSAMKssPQIPHQT
  rat

 
K4 ____MAEKFESLMNI
T54 AIKKIVLTDPQSVKH
S145 RGLKYIHSANVLHRD
K154 NVLHRDLKPANLFIN
Y182 ARIMDPHYSHKGHLS
S189 YSHKGHLSEGLVTKW
Y209 LLLSPNNYTKAIDMW
K276 NDMTEPHKPLTQLLP
Y357 HIYNWERYHDCQFSE
S363 RYHDCQFSEHDWPIH
S386 QLDPRALSDVTDEEE
T389 PRALSDVTDEEEVQV
S441 KYCDLECSHTCNYKT
K447 CSHTCNYKTRSPSYL
S450 TCNYKTRSPSYLDNL
S452 NYKTRSPSYLDNLVW
Y453 YKTRSPSYLDNLVWR
Y467 RESEVNHYYEPKLII
Y468 ESEVNHYYEPKLIID
K471 VNHYYEPKLIIDLSN
K480 IIDLSNWKEQSKDKS
S483 LSNWKEQSKDKSDKR
K502 CERNGLVKAQIALEE
S511 QIALEEASQQLAERE
- gap
S554 KLNDLNSSVSQLEMK
S556 NDLNSSVSQLEMKSL
K561 SVSQLEMKSLISKSV
K566 EMKSLISKSVSREKQ
K630 TYTSYLDKFFSRKED
K635 LDKFFSRKEDSEMLE
T643 EDSEMLETEPVEEGK
K650 TEPVEEGKRGERGRE
G664 EAGLLSSGGEFLLSR
S683 IGTPQFHSPGGSPLK
S687 QFHSPGGSPLKSIQA
T697 KSIQATLTPSAMKSS
S703 LTPSAMKSSPQIPHK
S704 TPSAMKSSPQIPHKT
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