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NOXA
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Interacts with MCL1, BCL2A1 and BAX. Up-regulated by p53/TP53, phorbol esters, double- stranded RNA, IFNB1/IFN-beta and viruses. Highly expressed in adult T-cell leukemia cell line. Belongs to the PMAIP1 family. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Mitochondrial |
| Chromosomal Location of Human Ortholog: 18q12.1 |
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Cellular Component: cytosol; mitochondrion; nucleus
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Biological Process: apoptosis; caspase activation; cellular response to glucose starvation; defense response to virus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of fibroblast proliferation; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of neuron apoptosis; positive regulation of protein oligomerization; proteasomal protein catabolic process; regulation of mitochondrial membrane permeability; release of cytochrome c from mitochondria; response to DNA damage stimulus; response to dsRNA; response to UV; response to X-ray; T cell homeostasis
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Reference #:
Q5U777
(UniProtKB)
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Alt. Names/Synonyms: Noxa; phorbol-12-myristate-13-acetate-induced protein 1; Pmaip1
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Gene Symbols: Pmaip1
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Molecular weight:
11,901 Da
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Basal Isoelectric point:
10.76
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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Mitochondrial Control of Apoptosis
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