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Protein Page:
Oct8 (human)

Overview
Oct8 Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3'). Belongs to the POU transcription factor family. Class- 3 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q12.1
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: central nervous system development; cerebral cortex radially oriented cell migration; forebrain ventricular zone progenitor cell division; negative regulation of apoptosis; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent
Reference #:  P20264 (UniProtKB)
Alt. Names/Synonyms: Brain-1; Brain-specific homeobox/POU domain protein 1; Brn-1; BRN1; Oct-8; Octamer-binding protein 8; Octamer-binding transcription factor 8; OTF-8; OTF8; POU domain, class 3, transcription factor 3
Gene Symbols: POU3F3
Molecular weight: 50,327 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Select Structure to View Below

Oct8

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S393‑p EADSSTGsPTSIDKI
  mouse

 
S390‑p EADSSTGsPTSIDKI
  rat

 
S390‑p EADSSTGsPTSIDKI
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