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Protein Page:
EN1 (human)

Overview
EN1 Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
Protein type: Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q14.2
Cellular Component: nucleus
Biological Process: anatomical structure morphogenesis; negative regulation of transcription from RNA polymerase II promoter; skeletal development
Reference #:  Q05925 (UniProtKB)
Alt. Names/Synonyms: HME1; Homeobox protein en-1; Homeobox protein engrailed-1; Hu-En-1
Gene Symbols: EN1
Molecular weight: 40,115 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
Select Structure to View Below

EN1

Protein Structure Not Found.


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