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Protein Page:
POLR2F (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
POLR2F DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and togther with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. Note: This description may include information from UniProtKB.
Protein type: Transcription initiation complex; EC 2.7.7.6; Nucleotide Metabolism - purine; RNA processing; Transferase; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: cytosol; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase III complex; nucleolus; nucleoplasm; nucleus
Biological Process: fibroblast growth factor receptor signaling pathway; gene expression; mRNA capping; nuclear mRNA splicing, via spliceosome; positive regulation of gene expression, epigenetic; positive regulation of interferon type I production; positive regulation of viral transcription; RNA elongation from RNA polymerase I promoter; RNA elongation from RNA polymerase II promoter; RNA-mediated gene silencing; snRNA transcription from RNA polymerase II promoter; somatic stem cell maintenance; termination of RNA polymerase I transcription; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter; transcription initiation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair
Reference #:  P61218 (UniProtKB)
Alt. Names/Synonyms: DNA directed RNA polymerase II 14.4 kda polypeptide; DNA-directed RNA polymerase II subunit F; DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide; DNA-directed RNA polymerases I, II, and III subunit RPABC2; HRBP14.4; POLR2F; POLRF; polymerase (RNA) II (DNA directed) polypeptide F; RNA Polymerase II subunit 14.4 kD; RNA polymerases I, II, and III subunit ABC2; RPAB2; RPABC14.4; RPABC2; RPB14.4; RPB6; RPB6 homolog; RPC15
Gene Symbols: POLR2F
Molecular weight: 14,478 Da
Basal Isoelectric point: 4.11  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Select Structure to View Below

POLR2F

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 3 S2‑p ______MsDNEDNFD
0 5 K59‑ub ITTPYMTkYERARVL
0 2 K101‑ub MKELKARkIPIIIRR
  mouse

 
S2‑p ______MsDNEDNFD
K59‑ub ITTPYMTkYERARVL
K101 MKELKARKIPIIIRR
  rat

 
S2‑p ______MsDNEDNFD
K59 ITTPYMTKYERARVL
K101 MKELKARKIPIIIRR
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