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Protein Page:
BRSK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BRSK2 a serine/threonine protein kinase of the CAMK group. Closely related to AMPK. Activated by the kinase LKB1. BRSK1 and BRSK2 are required for nueronal polarization. Expressed in the brain and at low levels in the testis. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, CAMK; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.26; CAMK group; CAMKL family; BRSK subfamily
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: centrosome; cytoplasm; endoplasmic reticulum; nucleus
Molecular Function: ATP binding; ATPase binding; magnesium ion binding; protein serine/threonine kinase activity; tau-protein kinase activity
Biological Process: actin cytoskeleton reorganization; axonogenesis; establishment of cell polarity; G2/M transition of mitotic cell cycle; neuron differentiation; protein amino acid phosphorylation
Reference #:  Q8IWQ3 (UniProtKB)
Alt. Names/Synonyms: BR serine/threonine kinase 2; BR serine/threonine-protein kinase 2; BRSK2; C11orf7; FLJ41362; PEN11B; protein kinase SAD1B; SAD1; serine/threonine kinase 29; serine/threonine kinase SAD-A; Serine/threonine-protein kinase 29; Serine/threonine-protein kinase SAD-A; STK29
Gene Symbols: BRSK2
Molecular weight: 81,633 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BRSK2

Protein Structure Not Found.
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Sites Implicated In
enzymatic activity, induced: T260‑p
enzymatic activity, inhibited: T443‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y15‑p GGAQHAQyVGPYRLE
0 2 Y19 HAQyVGPYRLEKTLG
0 1 K48‑ub TCQKVAIkIVNREKL
3 2 T174‑p VGDSLLEtSCGSPHY
0 1 S175 GDSLLEtSCGSPHYA
0 1 S178 LLEtSCGSPHYACPE
2 0 T260‑p VDAARRLtLEHIQKH
0 1 S291 PRKVQIRSLPsLEDI
0 7 S294‑p VQIRSLPsLEDIDPD
0 1 Y334 ENQEKMIYFLLLDRK
0 11 S367‑p PPRKRVDsPMLNRHG
0 15 S382‑p KRRPERKsMEVLSVT
0 1 T389 sMEVLSVTDGGsPVP
0 17 S393‑p LSVTDGGsPVPARRA
0 7 - gap
0 1 S410‑p MAQHGQRsRsISGAS
0 5 S412‑p QHGQRsRsISGASSG
0 1 S414 GQRsRsISGASSGLS
0 1 S417 sRsISGASSGLSTsP
0 1 S418 RsISGASSGLSTsPL
0 3 S421 SGASSGLSTsPLssP
0 4 T422 GASSGLSTsPLssPR
1 14 S423‑p ASSGLSTsPLssPRV
0 4 S426‑p GLSTsPLssPRVtPH
1 9 S427‑p LSTsPLssPRVtPHP
1 3 T431‑p PLssPRVtPHPsPrG
1 4 S435‑p PRVtPHPsPrGsPLP
0 1 R437‑m1 VtPHPsPrGsPLPtP
1 3 S439‑p PHPsPrGsPLPtPKG
2 1 T443‑p PrGsPLPtPKGTPVH
1 1 T447 PLPtPKGTPVHTPKE
1 1 T451 PKGTPVHTPKESPAG
1 3 S455 PVHTPKESPAGTPNP
1 1 T459 PKESPAGTPNPtPPs
1 6 T463‑p PAGTPNPtPPsSPSV
1 2 S466‑p TPNPtPPsSPSVGGV
1 0 S467 PNPtPPsSPSVGGVP
0 4 S481‑p PWRARLNsIKNSFLG
1 24 S489‑p IKNSFLGsPRFHRRK
1 1 T501 RRKLQVPTPEEMsNL
0 1 S506‑p VPTPEEMsNLtPEss
1 20 T509‑p PEEMsNLtPEssPEL
1 11 S512‑p MsNLtPEssPELAKK
1 14 S513‑p sNLtPEssPELAKKS
0 1 S520 sPELAKKSWFGNFIS
0 1 Y717 GPGGDAEYPTGKDTA
  BRSK2 iso2  
Y15 GGAQHAQYVGPYRLE
Y19 HAQYVGPYRLEKTLG
K48 TCQKVAIKIVNREKL
T174 VGDSLLETSCGSPHY
S175 GDSLLETSCGSPHYA
S178 LLETSCGSPHYACPE
T260 VDAARRLTLEHIQKH
S291 PRKVQIRSLPSLEDI
S294 VQIRSLPSLEDIDPD
Y334 ENQEKMIYFLLLDRK
S367 PPRKRVDSPMLNRHG
S382 KRRPERKSMEVLSVT
T389 SMEVLSVTDGGSPVP
S393 LSVTDGGSPVPARRA
- gap
S410 MAQHGQRSRSISGAS
S412 QHGQRSRSISGASSG
S414 GQRSRSISGASSGLS
S417 SRSISGASSGLSTSP
S418 RSISGASSGLSTSPL
S421 SGASSGLSTSPLSSP
T422 GASSGLSTSPLSSPR
S423 ASSGLSTSPLSSPRV
S426 GLSTSPLSSPRVTPH
S427 LSTSPLSSPRVTPHP
T431 PLSSPRVTPHPSPRG
S435 PRVTPHPSPRGSPLP
R437 VTPHPSPRGSPLPTP
S439 PHPSPRGSPLPTPKG
T443 PRGSPLPTPKGTPVH
T447 PLPTPKGTPVHTPKE
T451 PKGTPVHTPKESPAG
S455 PVHTPKESPAGTPNP
T459 PKESPAGTPNPTPPS
T463 PAGTPNPTPPSSPSV
S466 TPNPTPPSSPSVGGV
S467 PNPTPPSSPSVGGVP
S481 PWRARLNSIKNSFLG
S489 IKNSFLGSPRFHRRK
T501 RRKLQVPTPEEMSNL
S506 VPTPEEMSNLTPESS
T509 PEEMSNLTPESSPEL
S512 MSNLTPESSPELAKK
S513 SNLTPESSPELAKKS
S520 SPELAKKSWFGNFIS
- gap
  BRSK2 iso4  
Y15 GGAQHAQYVGPYRLE
Y19 HAQYVGPYRLEKTLG
K48 TCQKVAIKIVNREKL
T174 VGDSLLETSCGSPHY
S175 GDSLLETSCGSPHYA
S178 LLETSCGSPHYACPE
T260 VDAARRLTLEHIQKH
S291 PRKVQIRSLPSLEDI
S294 VQIRSLPSLEDIDPD
Y334 ENQEKMIYFLLLDRK
S367 PPRKRVDSPMLNRHG
S382 KRRPERKSMEVLSVT
T389 SMEVLSVTDGGSPVP
S393 LSVTDGGSPVPARRA
S416‑p SKAMFSKsLDIAEAH
S432 QFSKEDRSRSISGAS
S434 SKEDRSRSISGASSG
S436 EDRSRSISGASSGLS
S439 SRSISGASSGLSTsP
S440 RSISGASSGLSTsPL
S443 SGASSGLSTsPLSSP
T444 GASSGLSTsPLSSPR
S445‑p ASSGLSTsPLSSPRV
S448 GLSTsPLSSPRVTPH
S449 LSTsPLSSPRVTPHP
T453 PLSSPRVTPHPSPRG
S457 PRVTPHPSPRGSPLP
R459 VTPHPSPRGSPLPTP
S461 PHPSPRGSPLPTPKG
T465 PRGSPLPTPKGTPVH
T469 PLPTPKGTPVHTPKE
T473 PKGTPVHTPKESPAG
S477 PVHTPKESPAGTPNP
T481 PKESPAGTPNPTPPS
T485 PAGTPNPTPPSSPSV
S488 TPNPTPPSSPSVGGV
S489 PNPTPPSSPSVGGVP
S503 PWRARLNSIKNSFLG
S511 IKNSFLGSPRFHRRK
T523 RRKLQVPTPEEMSNL
S528 VPTPEEMSNLTPESS
T531 PEEMSNLTPESSPEL
S534 MSNLTPESSPELAKK
S535 SNLTPESSPELAKKS
S542 SPELAKKSWFGNFIS
- gap
  BRSK2 iso5  
- gap
- gap
K94 TCQKVAIKIVNREKL
T220 VGDSLLETSCGSPHY
S221 GDSLLETSCGSPHYA
S224 LLETSCGSPHYACPE
T306 VDAARRLTLEHIQKH
S337 PRKVQIRSLPSLEDI
S340 VQIRSLPSLEDIDPD
Y380 ENQEKMIYFLLLDRK
S413 PPRKRVDSPMLNRHG
S428 KRRPERKSMEVLSVT
T435 SMEVLSVTDGGSPVP
S439 LSVTDGGSPVPARRA
- gap
S456 MAQHGQRSRSISGAS
S458 QHGQRSRSISGASSG
S460 GQRSRSISGASSGLS
S463 SRSISGASSGLSTSP
S464 RSISGASSGLSTSPL
S467 SGASSGLSTSPLSSP
T468 GASSGLSTSPLSSPR
S469 ASSGLSTSPLSSPRV
S472 GLSTSPLSSPRVTPH
S473 LSTSPLSSPRVTPHP
T477 PLSSPRVTPHPSPRG
S481 PRVTPHPSPRGSPLP
R483 VTPHPSPRGSPLPTP
S485 PHPSPRGSPLPTPKG
T489 PRGSPLPTPKGTPVH
T493 PLPTPKGTPVHTPKE
T497 PKGTPVHTPKESPAG
S501 PVHTPKESPAGTPNP
T505 PKESPAGTPNPTPPS
T509 PAGTPNPTPPSSPSV
S512 TPNPTPPSSPSVGGV
S513 PNPTPPSSPSVGGVP
S527 PWRARLNSIKNSFLG
S535 IKNSFLGSPRFHRRK
T547 RRKLQVPTPEEMSNL
S552 VPTPEEMSNLTPESS
T555 PEEMSNLTPESSPEL
S558 MSNLTPESSPELAKK
S559 SNLTPESSPELAKKS
S566 SPELAKKSWFGNFIS
Y747 GPGGDAEYPTGKDTA
  BRSK2 iso6  
- gap
- gap
- gap
- gap
- gap
- gap
T200 VDAARRLTLEHIQKH
S231 PRKVQIRSLPSLEDI
S234 VQIRSLPSLEDIDPD
Y274 ENQEKMIYFLLLDRK
S307 PPRKRVDSPMLNRHG
S322 KRRPERKSMEVLSVT
T329 SMEVLSVTDGGSPVP
S333 LSVTDGGSPVPARRA
- gap
S350 MAQHGQRSRSISGAS
S352 QHGQRSRSISGASSG
S354 GQRSRSISGASSGLS
S357 SRSISGASSGLSTSP
S358 RSISGASSGLSTSPL
S361 SGASSGLSTSPLSSP
T362 GASSGLSTSPLSSPR
S363 ASSGLSTSPLSSPRV
S366 GLSTSPLSSPRVTPH
S367 LSTSPLSSPRVTPHP
T371 PLSSPRVTPHPSPRG
S375 PRVTPHPSPRGSPLP
R377 VTPHPSPRGSPLPTP
S379 PHPSPRGSPLPTPKG
T383 PRGSPLPTPKGTPVH
T387 PLPTPKGTPVHTPKE
T391 PKGTPVHTPKESPAG
S395 PVHTPKESPAGTPNP
T399 PKESPAGTPNPTPPS
T403 PAGTPNPTPPSSPSV
S406 TPNPTPPSSPSVGGV
S407 PNPTPPSSPSVGGVP
S421 PWRARLNSIKNSFLG
S429 IKNSFLGSPRFHRRK
T441 RRKLQVPTPEEMSNL
S446 VPTPEEMSNLTPESS
T449 PEEMSNLTPESSPEL
S452 MSNLTPESSPELAKK
S453 SNLTPESSPELAKKS
S460 SPELAKKSWFGNFIS
- gap
  mouse

 
Y16 GGAQHAQYVGPYRLE
Y20 HAQYVGPYRLEKTLG
K49 TCQKVAIKIVNREKL
T175‑p VGDSLLEtsCGsPHY
S176‑p GDSLLEtsCGsPHYA
S179‑p LLEtsCGsPHYACPE
T261 VDAARRLTLEHIQKH
S292‑p PRKVQIRsLPsLEDI
S295‑p VQIRsLPsLEDIDPD
Y335 ENQEKMIYFLLLDRK
S368‑p PPRKRVDsPMLNRHG
S383‑p KRRPERKsMEVLSVt
T390‑p sMEVLSVtDGGsPVP
S394‑p LSVtDGGsPVPARRA
- gap
S411 MAQHGQRSRsIsGAs
S413‑p QHGQRSRsIsGAssG
S415‑p GQRSRsIsGAssGLs
S418‑p SRsIsGAssGLstsP
S419‑p RsIsGAssGLstsPL
S422‑p sGAssGLstsPLssP
T423‑p GAssGLstsPLssPR
S424‑p AssGLstsPLssPRV
S427‑p GLstsPLssPRVtPH
S428‑p LstsPLssPRVtPHP
T432‑p PLssPRVtPHPsPRG
S436‑p PRVtPHPsPRGsPLP
R438 VtPHPsPRGsPLPtP
S440‑p PHPsPRGsPLPtPKG
T444‑p PRGsPLPtPKGtPVH
T448‑p PLPtPKGtPVHtPKE
T452‑p PKGtPVHtPKEsPAG
S456‑p PVHtPKEsPAGtPNP
T460‑p PKEsPAGtPNPtPPs
T464‑p PAGtPNPtPPssPSV
S467‑p tPNPtPPssPSVGGV
S468‑p PNPtPPssPSVGGVP
S482‑p PWRTRLNsIKNSFLG
S490‑p IKNSFLGsPRFHRRK
T502‑p RRKLQVPtPEEMSNL
S507 VPtPEEMSNLtPEss
T510‑p PEEMSNLtPEssPEL
S513‑p MSNLtPEssPELAKK
S514‑p SNLtPEssPELAKKs
S521‑p sPELAKKsWFGNFIN
Y716‑p GPGGDTEyPMGKDMA
  rat

 
Y16 GGAQHAQYVGPyRLE
Y20‑p HAQYVGPyRLEKTLG
K49 TCQKVAIKIVNREKL
T175 VGDSLLETSCGSPHY
S176 GDSLLETSCGSPHYA
S179 LLETSCGSPHYACPE
T261 VDAARRLTLEHIQKH
S292 PRKVQIRSLPsLEDI
S295‑p VQIRSLPsLEDIDPD
Y335‑p ENQEKMIyFLLLDRK
S368‑p PPRKRVDsPMLNRHG
S383‑p KRRPERKsMEVLSVT
T390 sMEVLSVTDGGsPVP
S394‑p LSVTDGGsPVPARRA
- gap
S411 MAQHGQRSRsISGAS
S413‑p QHGQRSRsISGASSG
S415 GQRSRsISGASSGLS
S418 SRsISGASSGLSTsP
S419 RsISGASSGLSTsPL
S422 SGASSGLSTsPLssP
T423 GASSGLSTsPLssPR
S424‑p ASSGLSTsPLssPRV
S427‑p GLSTsPLssPRVTPH
S428‑p LSTsPLssPRVTPHP
T432 PLssPRVTPHPSPRG
S436 PRVTPHPSPRGsPLP
R438 VTPHPSPRGsPLPTP
S440‑p PHPSPRGsPLPTPKG
T444 PRGsPLPTPKGTPVH
T448 PLPTPKGTPVHTPKE
T452 PKGTPVHTPKEsPAG
S456‑p PVHTPKEsPAGTPNP
T460 PKEsPAGTPNPtPPS
T464‑p PAGTPNPtPPSSPSV
S467 TPNPtPPSSPSVGGV
S468 PNPtPPSSPSVGGVP
S482 PWRTRLNSIKNSFLG
S490‑p IKNSFLGsPRFHRRK
T502 RRKLQVPTPEEMSNL
S507 VPTPEEMSNLTPESS
T510 PEEMSNLTPESSPEL
S513 MSNLTPESSPELGHL
S514 SNLTPESSPELGHLQ
Q521 SPELGHLQLFGNPVS
Y716 GPGGDTEYPMGKDMA
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