Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
ZP3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

ZP3 The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. Belongs to the ZP domain family. ZPC subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: acrosome; cytoplasm; endoplasmic reticulum; extracellular matrix; extracellular region; extracellular space; Golgi apparatus; multivesicular body; perinuclear region of cytoplasm; plasma membrane; secretory granule
Molecular Function: acrosin binding; carbohydrate binding; manganese ion transmembrane transporter activity; protein binding; signal transducer activity; store-operated calcium channel activity
Biological Process: binding of sperm to zona pellucida; blastocyst formation; humoral immune response mediated by circulating immunoglobulin; intracellular protein transport; manganese ion transport; negative regulation of transcription, DNA-dependent; oocyte development; phosphoinositide-mediated signaling; positive regulation of humoral immune response; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-4 production; positive regulation of leukocyte migration; positive regulation of phosphatidylinositol biosynthetic process; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling cascade; positive regulation of T cell proliferation; positive regulation of transcription, DNA-dependent; positive regulation of type IV hypersensitivity
Reference #:  P21754 (UniProtKB)
Alt. Names/Synonyms: P21754; P21754-2; P21754-3; zona pellucida glycoprotein 3; zona pellucida glycoprotein 3 (sperm receptor); zona pellucida glycoprotein 3A (sperm receptor); zona pellucida glycoprotein 3B; zona pellucida protein C; zona pellucida sperm-binding protein 3; zona pellucida sperm-binding protein 3 isoform 1; zona pellucida sperm-binding protein 3 isoform 2; ZP3; ZP3A; ZP3B; ZPC
Gene Symbols: ZP3
Molecular weight: 47,018 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.