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Protein Page:
DOR-1 (human)

Overview
DOR-1 delta opioid receptor, a G-protein coupled receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. Receptor for enkephalins. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36.1-p34.3
Cellular Component: integral to plasma membrane; intrinsic to plasma membrane; neuron projection; plasma membrane
Molecular Function: neuropeptide binding; opioid receptor activity; protein binding
Biological Process: activation of CREB transcription factor; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; negative regulation of protein oligomerization; neuropeptide signaling pathway; positive regulation of peptidyl-serine phosphorylation; protein import into nucleus, translocation; regulation of mitochondrial membrane potential; sensory perception of pain; synaptic transmission
Reference #:  P41143 (UniProtKB)
Alt. Names/Synonyms: D-OR-1; delta opioid receptor 1; Delta-type opioid receptor; DOR-1; opioid receptor, delta 1; OPRD; OPRD1
Gene Symbols: OPRD1
Molecular weight: 40,369 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
Select Structure to View Below

DOR-1

Protein Structure Not Found.
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Sites Implicated In
receptor desensitization, altered: S363‑p
receptor internalization, altered: S363‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
3 0 T161 VKALDFRTPAKAKLI
0 1 T211‑p SPSWYWDtVtKICVF
0 1 T213‑p SWYWDtVtKICVFLF
1 0 Y318 SSLNPVLYAFLDENF
1 0 S344 CGRPDPSSFSRAREA
1 0 T352 FSRAREATARERVtA
2 0 A353 SRAREATARERVtAC
4 0 T358‑p ATARERVtACtPsDG
3 0 T361‑p RERVtACtPsDGPGG
10 0 S363‑p RVtACtPsDGPGGGA
  mouse

 
T161‑p VKALDFRtPAKAKLI
T211 SPSWYWDTVTKICVF
T213 SWYWDTVTKICVFLF
Y318‑p SSLNPVLyAFLDENF
S344‑p CGRQEPGsLRRPRQA
T352‑p LRRPRQAttRERVtA
T353‑p RRPRQAttRERVtAC
T358‑p AttRERVtACtPsDG
T361‑p RERVtACtPsDGPGG
S363‑p RVtACtPsDGPGGGA
  rat

 
T161‑p VKALDFRtPAKAKLI
T211 SPSWYWDTVTKICVF
T213 SWYWDTVTKICVFLF
Y318 SSLNPVLYAFLDENF
S344 CGGQEPGSLRRPRQA
T352 LRRPRQATARERVTA
A353 RRPRQATARERVTAC
T358 ATARERVTACTPSDG
T361 RERVTACTPSDGPGG
S363 RVTACTPSDGPGGGA
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