a major structural protein of the eye lens. A member of the small heat shock protein (sHSP also known as the HSP20) family. Alpha-B is expressed in the lens as well as other tissues. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Note: This description may include information from UniProtKB.
Molecular Function: cytoskeletal protein binding; identical protein binding; microtubule binding; protein binding; protein homodimerization activity; structural constituent of eye lens; unfolded protein binding
Biological Process: camera-type eye development; lens development in camera-type eye; microtubule polymerization or depolymerization; muscle development; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of cell growth; negative regulation of intracellular transport; protein folding; protein homooligomerization; response to hydrogen peroxide; response to hypoxia; stress-activated MAPK cascade; tubulin folding