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Protein Page:
TAK1 (mouse)

TAK1 a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TAK1 subfamily; TKL group
Cellular Component: postsynaptic density
Molecular Function: MAP kinase kinase activity; MAP kinase kinase kinase activity; protein binding
Biological Process: activation of MAPKK activity; angiogenesis; I-kappaB phosphorylation; MAPKKK cascade; neural tube formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; protein amino acid phosphorylation; transforming growth factor beta receptor signaling pathway
Reference #:  Q62073 (UniProtKB)
Alt. Names/Synonyms: B430101B05; C87327; M3K7; Map3k7; mitogen activated protein kinase kinase kinase 7; Mitogen-activated protein kinase kinase kinase 7; OTTMUSP00000005100; Tak1; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor beta-activated kinase 1; Transforming growth factor-beta-activated kinase 1
Gene Symbols: Map3k7
Molecular weight: 64,228 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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