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Protein Page:
TAK1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TAK1 a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; TAK1 subfamily
Molecular Function: MAP kinase kinase activity; MAP kinase kinase kinase activity; protein binding
Biological Process: activation of MAPKK activity; angiogenesis; I-kappaB phosphorylation; MAPKKK cascade; neural tube formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; protein amino acid phosphorylation; transforming growth factor beta receptor signaling pathway
Reference #:  Q62073 (UniProtKB)
Alt. Names/Synonyms: B430101B05; C87327; M3K7; Map3k7; mitogen activated protein kinase kinase kinase 7; Mitogen-activated protein kinase kinase kinase 7; OTTMUSP00000005100; Tak1; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor beta-activated kinase 1; Transforming growth factor-beta-activated kinase 1
Gene Symbols: Map3k7
Molecular weight: 64,228 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TAK1

Protein Structure Not Found.
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Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell differentiation, altered: S412‑p
transcription, altered: S412‑p
enzymatic activity, induced: S192‑p
phosphorylation: S412‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
1 0 K72 IESESERKAFIVELR
2 0 K158 ALIHRDLKPPNLLLV
2 0 T178 LKICDFGTACDIQtH
11 0 T184‑p GTACDIQtHMtNNKG
18 0 T187‑p CDIQtHMtNNKGsAA
4 0 S192‑p HMtNNKGsAAWMAPE
2 0 K209 EGSNYSEKCDVFSWG
0 1 T333 NTSNKSDTNMEQVPA
0 1 K346 PATNDTIKRLESKLL
0 1 K351 TIKRLESKLLKNQAK
0 1 K354 RLESKLLKNQAKQQs
0 1 S361‑p KNQAKQQsESGRLsL
0 4 S367‑p QsESGRLsLGAsRGS
0 2 S371‑p GRLsLGAsRGSSVES
0 1 S375 LGAsRGSSVESLPPT
0 1 K386 LPPTSEGKRMsADMs
0 40 S389‑p TSEGKRMsADMsEIE
0 2 S393‑p KRMsADMsEIEARIV
0 9 - gap
0 1 - gap
0 2 - gap
0 8 - gap
2 128 S412‑p NGQPRRRsIQDLtVT
0 3 T417‑p RRsIQDLtVTGTEPG
0 5 S427‑p GTEPGQVssRSSSPS
0 8 S428‑p TEPGQVssRSSSPSV
0 1 S431 GQVssRSSSPSVRMI
0 1 S432 QVssRSSSPSVRMIT
0 1 S445 ITTSGPTSEKPARSH
0 1 S465‑p DSTDTNGsDNSIPMA
0 1 K520 IALLLQRKQELVAEL
0 1 K546 RLVQEHKKLLDENKS
0 2 Y557 ENKSLSTYYQQCKkQ
0 2 Y558 NKSLSTYYQQCKkQL
0 2 K563‑ub TYYQQCKkQLEVIRS
4508 : Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb
4531 : Phospho-TAK1 (Thr184/187) Antibody
4537 : Phospho-TAK1 (Thr184) Antibody
4508 : Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb
4531 : Phospho-TAK1 (Thr184/187) Antibody
4536 : Phospho-TAK1 (Thr187) Antibody
9339 : Phospho-TAK1 (Ser412) Antibody
  TAK1 iso3  
K72 IESESERKAFIVELR
K158 ALIHRDLKPPNLLLV
T178 LKICDFGTACDIQTH
T184 GTACDIQTHMTNNKG
T187 CDIQTHMTNNKGSAA
S192 HMTNNKGSAAWMAPE
K209 EGSNYSEKCDVFSWG
T333 NTSNKSDTNMEQVPA
K346 PATNDTIKRLESKLL
K351 TIKRLESKLLKNQAK
K354 RLESKLLKNQAKQQS
S361 KNQAKQQSESGRLSL
S367 QSESGRLSLGASRGS
S371 GRLSLGASRGSSVES
S375 LGASRGSSVESLPPT
K386 LPPTSEGKRMSADMS
S389 TSEGKRMSADMSEIE
S393 KRMSADMSEIEARIV
Y405‑p RIVATAAySKPKRGH
S406 IVATAAySKPKRGHR
T415‑p PKRGHRKtAsFGNIL
S417‑p RGHRKtAsFGNILDV
S439 NGQPRRRSIQDLTVT
T444 RRSIQDLTVTGTEPG
S454 GTEPGQVSSRSSSPS
S455 TEPGQVSSRSSSPSV
S458 GQVSSRSSSPSVRMI
S459 QVSSRSSSPSVRMIT
S472 ITTSGPTSEKPARSH
S492 DSTDTNGSDNSIPMA
K547 IALLLQRKQELVAEL
K573 RLVQEHKKLLDENKS
Y584 ENKSLSTYYQQCKKQ
Y585 NKSLSTYYQQCKKQL
K590 TYYQQCKKQLEVIRS
  human

 
K72‑ub IESESERkAFIVELR
K158‑ub ALIHRDLkPPNLLLV
T178‑p LKICDFGtACDIQtH
T184‑p GtACDIQtHMtNNKG
T187‑p CDIQtHMtNNKGsAA
S192‑p HMtNNKGsAAWMAPE
K209‑ub EGSNYSEkCDVFSWG
T333‑p NTSNKSDtNMEQVPA
K346‑ub PATNDTIkRLESkLL
K351‑ub TIkRLESkLLkNQAK
K354‑ub RLESkLLkNQAKQQs
S361‑p kNQAKQQsESGRLsL
S367‑p QsESGRLsLGAsRGS
S371‑p GRLsLGAsRGSsVES
S375‑p LGAsRGSsVESLPPT
K386‑ac LPPTSEGkRMsADMs
S389‑p TSEGkRMsADMsEIE
S393‑p kRMsADMsEIEARIA
Y405‑p RIAATTAysKPKRGH
S406‑p IAATTAysKPKRGHR
T415‑p PKRGHRKtAsFGNIL
S417‑p RGHRKtAsFGNILDV
S439‑p NGQPRRRsIQDLtVT
T444‑p RRsIQDLtVTGTEPG
S454‑p GTEPGQVssRSssPS
S455‑p TEPGQVssRSssPSV
S458‑p GQVssRSssPSVRMI
S459‑p QVssRSssPSVRMIT
S472‑p ITTSGPTsEKPTRSH
S492 DSTDTNGSDNSIPMA
K547‑ub IALLLQRkQELVAEL
K573‑ac RLVQEHKkLLDENKS
Y584‑p ENKSLSTyyQQCKkQ
Y585‑p NKSLSTyyQQCKkQL
K590‑ub TyyQQCKkQLEVIRS
4508 : Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb
4531 : Phospho-TAK1 (Thr184/187) Antibody
4537 : Phospho-TAK1 (Thr184) Antibody
4508 : Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb
4531 : Phospho-TAK1 (Thr184/187) Antibody
4536 : Phospho-TAK1 (Thr187) Antibody
9339 : Phospho-TAK1 (Ser412) Antibody
  rat

 
K72 IESESERKAFIVELR
K158 ALIHRDLKPPNLLLV
T178 LKICDFGTACDIQTH
T184 GTACDIQTHMtNNKG
T187‑p CDIQTHMtNNKGSAA
S192 HMtNNKGSAAWMAPE
K209 EGSNYSEKCDVFSWG
T333 NTSNKSDTNMEQVPA
K346 PATNDTIKRLESKLL
K351 TIKRLESKLLKNQAK
K354 RLESKLLKNQAKQQS
S361 KNQAKQQSDSGRLSL
S367 QSDSGRLSLGASRGS
S371 GRLSLGASRGSSVES
S375 LGASRGSSVESLPPT
K386 LPPTSEGKRMsADMS
S389‑p TSEGKRMsADMSEIE
S393 KRMsADMSEIEARIV
Y405 RIVATTAYTKPKRGH
T406 IVATTAYTKPKRGHR
T415 PKRGHRKTAsFGNIL
S417‑p RGHRKTAsFGNILDV
S439‑p NGQPRRRsIQDLTVT
T444 RRsIQDLTVTGTEPG
S454 GTEPGQVSSRSSSPS
S455 TEPGQVSSRSSSPSV
S458 GQVSSRSSSPSVRMI
S459 QVSSRSSSPSVRMIT
S472 ITTSGPTSEKPARSL
S492 DSTDTNGSDNSIPMA
K547 IALLLQRKQELVAEL
K573 RLVQEHKKLLDENKS
Y584 ENKSLSTYYQQCKKQ
Y585 NKSLSTYYQQCKKQL
K590 TYYQQCKKQLEVIRS
4508 : Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb
4531 : Phospho-TAK1 (Thr184/187) Antibody
4537 : Phospho-TAK1 (Thr184) Antibody
4508 : Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb
4531 : Phospho-TAK1 (Thr184/187) Antibody
4536 : Phospho-TAK1 (Thr187) Antibody
9339 : Phospho-TAK1 (Ser412) Antibody
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