a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Other group; IKK family
Cellular Component: cytoplasm
Molecular Function: nucleic acid binding; phosphoprotein binding; protein binding; protein serine/threonine kinase activity
Biological Process: activation of innate immune response; defense response to Gram-positive bacterium; peptidyl-serine phosphorylation; positive regulation of interferon-alpha production; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of transcription from RNA polymerase II promoter
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.