Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
TBK1 (mouse)

Overview
TBK1 a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; IKK family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Cellular Component: cytoplasm
Molecular Function: nucleic acid binding; phosphoprotein binding; protein binding; protein serine/threonine kinase activity
Biological Process: activation of innate immune response; defense response to Gram-positive bacterium; peptidyl-serine phosphorylation; positive regulation of interferon-alpha production; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q9WUN2 (UniProtKB)
Alt. Names/Synonyms: 1200008B05Rik; AI462036; AW048562; MGC150301; MGC150302; serine/threonine protein kinase TBK1; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; Tbk1
Gene Symbols: Tbk1
Molecular weight: 83,425 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TBK1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

Substrate Sequence Logo
Sequence Logo

STRING  |  Reactome  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene