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Protein Page:
TBK1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TBK1 a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Other group; IKK family
Cellular Component: cytoplasm
Molecular Function: nucleic acid binding; phosphoprotein binding; protein binding; protein serine/threonine kinase activity
Biological Process: activation of innate immune response; defense response to Gram-positive bacterium; peptidyl-serine phosphorylation; positive regulation of interferon-alpha production; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q9WUN2 (UniProtKB)
Alt. Names/Synonyms: 1200008B05Rik; AI462036; AW048562; MGC150301; MGC150302; serine/threonine protein kinase TBK1; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; Tbk1
Gene Symbols: Tbk1
Molecular weight: 83,425 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TBK1

Protein Structure Not Found.
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Substrate Sequence Logo
Sequence Logo

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 0 K30‑ac VFRGRHKkTGDLYAV
1 0 K30 VFRGRHKKTGDLYAV
0 1 K38‑ub TGDLYAVkVFNNISF
1 0 K69 LNHKNIVKLFAIEEE
0 1 S151 VIGEDGQSVYkLTDF
0 3 Y153 GEDGQSVYkLTDFGA
1 0 K154‑ac EDGQSVYkLTDFGAA
1 3 K154 EDGQSVYKLTDFGAA
12 49 S172‑p EDDEQFVsLYGTEEY
0 3 Y174 DEQFVsLYGTEEYLH
1 0 K236‑ac RNKEVMYkIITGkPS
1 0 K241‑ac MYkIITGkPSGAISG
0 1 K241 MYkIITGKPSGAISG
0 1 S247 GkPSGAISGVQkAEN
1 0 K251‑ac GAISGVQkAENGPID
0 1 T278 QGLQALLTPVLANIL
0 1 K291 ILEADQEKCWGFDQF
0 1 K344 ELVYKQTKIVSSNQE
0 2 Y354 SSNQELIYEGRRLVL
1 0 K372 RLAQHFPKTTEENPI
0 1 K396 TVGLRYEKISLPKIH
1 0 K401 YEKISLPKIHPRYDL
0 1 S499‑p AAELGEIsDIHTKLL
0 1 T503 GEIsDIHTKLLRLSS
0 1 K504 EIsDIHTKLLRLSSS
0 1 S511 KLLRLSSSQGTIESS
1 0 S527 QDISSRLSPGGLLAD
0 1 K584 YNEEQIHKFDKQKLY
1 0 K646‑ac DIEEEVSkYQDYTNE
0 1 K661 LQETLPQKMLAASGG
0 1 A664 TLPQKMLAASGGVKH
1 0 K691‑ac VEMTLGMkKLKEEME
1 17 S716‑p HILERFGsLTMDGGL
5483 : Phospho-TBK1/NAK (Ser172) (D52C2) XP(R) Rabbit mAb
13498 : Phospho-TBK1/NAK (Ser172) (D52C2) XP(R) Rabbit mAb (PE Conjugate)
  human

 
K30 VFRGRHKKTGDLFAI
K30‑ub VFRGRHKkTGDLFAI
K38 TGDLFAIKVFNNISF
K69‑ub LNHKNIVkLFAIEEE
S151‑p VIGEDGQsVykLTDF
Y153‑p GEDGQsVykLTDFGA
K154 EDGQsVyKLTDFGAA
K154‑ub EDGQsVykLTDFGAA
S172‑p EDDEQFVsLyGTEEY
Y174‑p DEQFVsLyGTEEYLH
K236 RNKEVMYKIITGkPS
K241 MYKIITGKPSGAIsG
K241‑ub MYKIITGkPSGAIsG
S247‑p GkPSGAIsGVQKAEN
K251 GAIsGVQKAENGPID
T278‑p RGLQVLLtPVLANIL
K291‑ub ILEADQEkCWGFDQF
K344‑ub ELVYKQTkIISSNQE
Y354‑p SSNQELIyEGRRLVL
K372‑ub RLAQHFPkTTEENPI
K396‑ub TIGLIYEkISLPkVH
K401‑ub YEkISLPkVHPRYDL
S499 AAELGEISDIHtkLL
T503‑p GEISDIHtkLLRLSS
K504‑ub EISDIHtkLLRLSSs
S511‑p kLLRLSSsQGTIETS
S527‑p QDIDSRLsPGGSLAD
K584‑ub YNEEQIHkFDKQKLY
K646 DIEEEVSKYQEYTNE
K661‑ub LQETLPQkMFtASSG
T664‑p TLPQkMFtASSGIKH
K691 VEMTLGMKKLKEEME
S716‑p HILERFGsLTMDGGL
5483 : Phospho-TBK1/NAK (Ser172) (D52C2) XP(R) Rabbit mAb
13498 : Phospho-TBK1/NAK (Ser172) (D52C2) XP(R) Rabbit mAb (PE Conjugate)
  rat

 
K30 VFRGRHKKTGDLYAV
K30 VFRGRHKKTGDLYAV
K38 TGDLYAVKVFNNISF
K69 LNHKNIVKLFAIEEE
S151 VIGEDGQSVyKLTDF
Y153‑p GEDGQSVyKLTDFGA
K154 EDGQSVyKLTDFGAA
K154 EDGQSVyKLTDFGAA
S172 EDDEQFVSLYGTEEY
Y174 DEQFVSLYGTEEYLH
K236 RNKEVMYKIITGKPS
K241 MYKIITGKPSGAISG
K241 MYKIITGKPSGAISG
S247 GKPSGAISGVQKAEN
K251 GAISGVQKAENGPID
T278 QGLQALLTPVLANIL
K291 ILEADQEKCWGFDQF
K344 ELVYKQTKIISSNQE
Y354 SSNQELIYEGRRLVL
K372 RLAQHFPKTTEENPI
K396 SIGLRYEKISLPKIH
K401 YEKISLPKIHPRYDL
S499 AAELGEISDIHTKLL
T503 GEISDIHTKLLRLSS
K504 EISDIHTKLLRLSSS
S511 KLLRLSSSQGTIESS
S527 QDINSRLSPGGSLAD
K584 YNEEQIHKFDKQKLY
K646 DIEEEVSKYQDYTNE
K661 LQETLPQKMLAASSG
A664 TLPQKMLAASSGIKH
K691 VEMTLGMKKLKEEME
S716 HILERFGSLTMDGGL
5483 : Phospho-TBK1/NAK (Ser172) (D52C2) XP(R) Rabbit mAb
13498 : Phospho-TBK1/NAK (Ser172) (D52C2) XP(R) Rabbit mAb (PE Conjugate)
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