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Protein Page:
PLCB2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PLCB2 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; Phospholipase; EC 3.1.4.11
Chromosomal Location of Human Ortholog: 15q15
Cellular Component: cytosol
Molecular Function: calcium ion binding; phosphoinositide phospholipase C activity; phospholipase C activity; signal transducer activity
Biological Process: inositol phosphate metabolic process; lipid catabolic process; phospholipase C activation; phospholipid metabolic process; sensory perception of bitter taste; synaptic transmission
Reference #:  Q00722 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2; FLJ38135; Phosphoinositide phospholipase C-beta-2; phospholipase C, beta 2; Phospholipase C-beta-2; PLC-beta-2; PLCB2
Gene Symbols: PLCB2
Molecular weight: 134,024 Da
Basal Isoelectric point: 5.96  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs
Select Structure to View Below

PLCB2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S2‑p ______MsLLNPVLL
0 1 S145 LTANASRSTFLDKIL
0 1 T146 TANASRSTFLDKILV
0 1 Y208‑p EDFPEPVyKSFLMSL
0 1 Y274‑p VQGLIDKyEPsGINA
0 1 S277‑p LIDKyEPsGINAQRG
0 1 T332‑p SSHNTYLtAGQFsGL
0 1 S337‑p YLtAGQFsGLSSAEM
0 1 S450‑p KPGVPLPsPEDLRGK
0 1 K461 LRGKILIKNKKNQFS
0 1 S472 NQFSGPTSSsKDTGG
0 1 S474‑p FSGPTSSsKDTGGEA
0 1 Y552‑p EMSSLVNyIQPTKFV
0 1 S601‑p DYNKRQMsRIyPKGT
0 1 Y604‑p KRQMsRIyPKGTRMD
0 1 S672‑p DKQFNPFsVDRIDVV
0 1 S698‑p GQFLSERsVRtYVEV
0 1 T701‑p LSERsVRtYVEVELF
0 1 Y718‑p PGDPKRRyRTKLSPS
0 1 S728‑p KLSPSTNsINPVWKE
0 1 K761‑ub AVMEEGNkFLGHRII
0 1 R874‑m1 PAARAGArEEAMKEA
0 1 R893‑m1 TASLEELrELKGVVK
0 10 S953‑p KLGPGKGsRKKRsLP
0 2 S958‑p KGsRKKRsLPREESA
0 1 T1035‑p ELKALKEtsENDtKE
0 1 S1036‑p LKALKEtsENDtKEM
0 1 T1040‑p KEtsENDtKEMKKKL
0 1 K1132 AEYEARMKGLEAEVK
  PLCB2 iso2  
S2 ______MSLLNPVLL
S145 LTANASRSTFLDKIL
T146 TANASRSTFLDKILV
Y208 EDFPEPVYKSFLMSL
Y274 VQGLIDKYEPSGINA
S277 LIDKYEPSGINAQRG
T332 SSHNTYLTAGQFSGL
S337 YLTAGQFSGLSSAEM
S450 KPGVPLPSPEDLRGK
K461 LRGKILIKNKKNQFS
S472 NQFSGPTSSSKDTGG
S474 FSGPTSSSKDTGGEA
Y548 EMSSLVNYIQPTKFV
S597 DYNKRQMSRIYPKGT
Y600 KRQMSRIYPKGTRMD
S668 DKQFNPFSVDRIDVV
S694 GQFLSERSVRTYVEV
T697 LSERSVRTYVEVELF
Y714 PGDPKRRYRTKLSPS
S724 KLSPSTNSINPVWKE
K757 AVMEEGNKFLGHRII
R870 PAARAGAREEAMKEA
R889 TASLEELRELKGVVK
S949 KLGPGKGSRKKRSLP
S954 KGSRKKRSLPREESA
T1031 ELKALKETSENDTKE
S1032 LKALKETSENDTKEM
T1036 KETSENDTKEMKKKL
K1128 AEYEARMKGLEAEVK
  PLCB2 iso3  
S2 ______MSLLNPVLL
S145 LTANASRSTFLDKIL
T146 TANASRSTFLDKILV
Y208 EDFPEPVYKSFLMSL
Y274 VQGLIDKYEPSGINA
S277 LIDKYEPSGINAQRG
T332 SSHNTYLTAGQFSGL
S337 YLTAGQFSGLSSAEM
S450 KPGVPLPSPEDLRGK
K461 LRGKILIKNKKNQFS
S472 NQFSGPTSSSKDTGG
S474 FSGPTSSSKDTGGEA
Y552 EMSSLVNYIQPTKFV
S601 DYNKRQMSRIYPKGT
Y604 KRQMSRIYPKGTRMD
S672 DKQFNPFSVDRIDVV
S698 GQFLSERSVRTYVEV
T701 LSERSVRTYVEVELF
Y718 PGDPKRRYRTKLSPS
S728 KLSPSTNSINPVWKE
K761 AVMEEGNKFLGHRII
- gap
R878 TASLEELRELKGVVK
S938 KLGPGKGSRKKRSLP
S943 KGSRKKRSLPREESA
T1020 ELKALKETSENDTKE
S1021 LKALKETSENDTKEM
T1025 KETSENDTKEMKKKL
K1117 AEYEARMKGLEAEVK
  mouse

 
S2 ______MSLLNPVLL
S145‑p MTVNAPRstFLDKIL
T146‑p TVNAPRstFLDKILV
Y208 EDFPESVYKSFLMSL
Y274 VQVLIDKYEPSGINV
S277 LIDKYEPSGINVQRG
T332 SSHNTYLTAGQFSGL
S337 YLTAGQFSGLSSAEM
S450 KPGIPLPSPEDLRGK
K461 LRGKILIKNKKNQFS
S472‑p NQFSGPAsPSKKPGG
S474 FSGPAsPSKKPGGVA
Y553 EMSSLVNYIQPTKFI
S602 DYNKRQMSRVYPKGT
Y605 KRQMSRVYPKGTRMD
S673 DKQFNPFSVDRIDVV
S699 GQFLSERSVRTYVEV
T702 LSERSVRTYVEVELF
Y719 PGDPKRRYRTKLSPT
S729 KLSPTANSINPVWKE
K762 AVMEEGSKFLGHRII
T874 TAPGTKATGEEATKE
R894 TASLEELRELKGVVK
S950 KLRPGKGSRKKRTLP
T955 KGSRKKRTLPCEETV
T1031 ELKTFKETSETDTKE
S1032 LKTFKETSETDTKEM
T1036 KETSETDTKEMKKKL
K1128 AEYEAKMKGLEAEVK
  rat

 
S2 ______MSLLNPVLL
S145 MTANASRSTFLDKIL
T146 TANASRSTFLDKILV
Y208 EDFPESVYKSFLMSL
Y274 VQALIDKYEPSGINV
S277 LIDKYEPSGINVQRG
T332 SSHNTYLTAGQFSGP
S337 YLTAGQFSGPSSAEM
S450 KPGMPLPSPEDLRGK
K461‑ub LRGKILIkNKKNQFS
S472 NQFSGPASPNKKPDG
N474 FSGPASPNKKPDGVS
Y556 EMSSLVNYIQPTKFI
S605 DYNKRQMSRVYPKGT
Y608 KRQMSRVYPKGTRMD
S676 DKQFNPFSVDRIDVV
S702 GQFLSERSVRTYVEV
T705 LSERSVRTYVEVELF
Y722 PGDPKRRYRTKLSPT
S732 KLSPTANSINPVWKE
K765 AVMEEGGKFIGHRII
K877 TAPGTKAKEEATKEV
R896 TTSLEELRELKGVVK
S952 KLRPGKGSRKKRIVP
I957 KGSRKKRIVPCEETI
T1033 ELKSFKETSETDTKE
S1034 LKSFKETSETDTKEM
T1038 KETSETDTKEMKKKL
K1130‑ac AEYEAKMkGLEAEVK
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