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Protein Page:
CYP1A1 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CYP1A1 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Amino Acid Metabolism - tryptophan; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; mitochondrion
Molecular Function: demethylase activity; enzyme binding; flavonoid 3'-monooxygenase activity; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on diphenols and related substances as donors; oxygen binding; protein binding; steroid hydroxylase activity
Biological Process: 9-cis-retinoic acid biosynthetic process; aging; amine metabolic process; arachidonic acid metabolic process; camera-type eye development; cell proliferation; cellular lipid metabolic process; coumarin metabolic process; dibenzo-p-dioxin catabolic process; drug metabolic process; embryonic development ending in birth or egg hatching; epoxygenase P450 pathway; flavonoid metabolic process; gut development; hydrogen peroxide biosynthetic process; insecticide metabolic process; maternal process involved in parturition; porphyrin metabolic process; response to antibiotic; response to arsenic; response to drug; response to food; response to herbicide; response to hyperoxia; response to hypoxia; response to iron(III) ion; response to lipopolysaccharide; response to nematode; response to virus; response to vitamin A; response to wounding; vitamin D metabolic process; xenobiotic metabolic process
Reference #:  P04798 (UniProtKB)
Alt. Names/Synonyms: AHH; AHRR; aryl hydrocarbon hydroxylase; CP11; CP1A1; CYP1; CYP1A1; CYPIA1; cytochrome P1-450, dioxin-inducible; Cytochrome P450 1A1; Cytochrome P450 form 6; cytochrome P450, family 1, subfamily A, polypeptide 1; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; Cytochrome P450-C; Cytochrome P450-P1; flavoprotein-linked monooxygenase; P1-450; P450-C; P450DX
Gene Symbols: CYP1A1
Molecular weight: 58,165 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Select Structure to View Below

CYP1A1

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 P31 WVIRASRPQVPKGLK
0 2 R93 LSGLDTIRQALVRQG
0 3 K104 VRQGDDFKGRPDLYT
0 1 S247‑p LRYLPNPsLNAFKDL
0 1 Y270‑p QKMVKEHykTFEKGH
0 1 K271‑ub KMVKEHykTFEKGHI
0 1 S360‑p RSRRPRLsDRSHLPY
  mouse

 
T35‑p WVVRATRtWVPKGLK
K97‑ub LSGLNTIkQALVRQG
K108‑ac VRQGDDFkGRPDLYS
S251 LRYLPNSSLDAFKDL
Y274 KKLIKEHYRTFEKGH
R275 KLIKEHYRTFEKGHI
S364 RDRQPRLSDRPQLPY
  rat

 
T35 WVVRVTRTWVPKGLK
K97 LSGLNTIKQALVKQG
K108 VKQGDDFKGRPDLYS
S251 LRYLPNSSLDAFKDL
Y274 KKLIKEHYRTFEKGH
R275 KLIKEHYRTFEKGHI
S364 RDRQPRLSDRPQLPY
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