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Protein Page:
CLCF1 (human)

Overview
CLCF1 Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Secreted, signal peptide; Secreted; Cytokine
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: extracellular region; intracellular
Molecular Function: ciliary neurotrophic factor receptor binding; cytokine activity; growth factor activity; protein binding; protein heterodimerization activity; receptor binding
Biological Process: B cell differentiation; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; JAK-STAT cascade; negative regulation of neuron apoptosis; positive regulation of astrocyte differentiation; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of immunoglobulin production; positive regulation of isotype switching to IgE isotypes; positive regulation of tyrosine phosphorylation of Stat3 protein
Disease: Cold-induced Sweating Syndrome 2
Reference #:  Q9UBD9 (UniProtKB)
Gene Symbols: CLCF1
Molecular weight: 25,176 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Select Structure to View Below

CLCF1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S56‑p YLEHQLRsLAGtYLN
0 1 T60‑p QLRsLAGtYLNYLGP
0 1 S96‑p VDLEVWRsLNDKLRL
  mouse

 
S56 YLEHQLRSLAGTYLN
T60 QLRSLAGTYLNYLGP
S96 VNLEVWRSLNDRLRL
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