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Protein Page:
MBL2 (human)

Overview
MBL2 Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: cell surface; extracellular region; extracellular space
Molecular Function: calcium ion binding; calcium-dependent protein binding; mannose binding; protein binding; receptor binding; serine-type endopeptidase activity
Biological Process: acute-phase response; complement activation; complement activation, lectin pathway; defense response to bacterium; defense response to Gram-positive bacterium; innate immune response; negative regulation of viral reproduction; opsonization
Disease: Mannose-binding Protein Deficiency
Reference #:  P11226 (UniProtKB)
Gene Symbols: MBL2
Molecular weight: 26,144 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
Select Structure to View Below

MBL2

Protein Structure Not Found.
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