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Protein Page:
MBL2 (human)

Overview
MBL2 Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: cell surface; collagen; extracellular region; extracellular space
Molecular Function: calcium ion binding; calcium-dependent protein binding; mannose binding; protein binding; receptor binding; serine-type endopeptidase activity
Biological Process: acute-phase response; complement activation; complement activation, classical pathway; complement activation, lectin pathway; defense response to bacterium; defense response to Gram-positive bacterium; innate immune response; killing by host of symbiont cells; negative regulation of viral reproduction; opsonization; positive regulation of phagocytosis; proteolysis; response to oxidative stress
Disease: Mannose-binding Protein Deficiency
Reference #:  P11226 (UniProtKB)
Gene Symbols: MBL2
Molecular weight: 26,144 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
Select Structure to View Below

MBL2

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S100‑p QKGDPGKsPDGDSSL
0 1 S110‑p GDSSLAAsERKALQT
0 1 T187 EEAFLGITDEKTEGQ
  mouse

 
R96 PKGDRGDRAEFDTSE
S106 FDTSEIDSEIAALRS
T183‑p DIAYLGItDVRVEGS
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