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Protein Page:
GALR1 (human)

Overview
GALR1 Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q23
Cellular Component: cytosol; integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: galanin receptor activity; neuropeptide binding; peptide hormone binding; protein binding
Biological Process: digestion; elevation of cytosolic calcium ion concentration; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); negative regulation of adenylate cyclase activity; neuropeptide signaling pathway; positive regulation of cortisol secretion; positive regulation of transcription from RNA polymerase II promoter
Reference #:  P47211 (UniProtKB)
Alt. Names/Synonyms: GAL1-R; galanin receptor 1; Galanin receptor type 1; GALNR; GALNR1; GALR-1; GALR1
Gene Symbols: GALR1
Molecular weight: 38,953 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
Select Structure to View Below

GALR1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S143‑p AIVHSRRssSLRVSR
0 2 S144‑p IVHSRRssSLRVSRN
0 2 Y209‑p VCTFVFGyLLPLLLI
0 2 Y220‑p LLLICFCyAKVLNHL
  mouse

 
S143 AIVHSRRSSSLRVSR
S144 IVHSRRSSSLRVSRN
Y208 VCTFVFGYLLPLLLI
Y219 LLLICFCYAKVLNHL
  rat

 
S142 AIVHSRRSSSLRVSR
S143 IVHSRRSSSLRVSRN
Y207 VCTFVFGYLLPLLLI
Y218 LLLICFCYAKVLNHL
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