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NDN
Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of Human Ortholog: 15q11.2 |
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Cellular Component: cytosol; nucleoplasm
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Biological Process: nervous system development
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Disease: Prader-willi Syndrome
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Reference #:
Q99608
(UniProtKB)
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Alt. Names/Synonyms: HsT16328; NDN; NECD; Necdin; necdin homolog (mouse); PWCR
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Gene Symbols: NDN
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Molecular weight:
36,086 Da
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Basal Isoelectric point:
8.81
Predict pI for various phosphorylation states
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