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Protein Page:
RPL10A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RPL10A a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Protein type: Ribosomal; Translation
Chromosomal Location of Human Ortholog: 6p21.31
Cellular Component: cytoplasm; cytosol; focal adhesion; membrane; nucleolus; nucleus
Molecular Function: protein binding; RNA binding
Biological Process: maturation of LSU-rRNA; mRNA catabolic process, nonsense-mediated decay; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription
Reference #:  P62906 (UniProtKB)
Alt. Names/Synonyms: 60S ribosomal protein L10a; CSA-19; NEDD-6; NEDD6; Neural precursor cell expressed developmentally down-regulated protein 6; ribosomal protein L10a; RL10A; RPL10A
Gene Symbols: RPL10A
Molecular weight: 24,831 Da
Basal Isoelectric point: 9.94  Predict pI for various phosphorylation states
Select Structure to View Below

RPL10A

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T9‑p SSKVSRDtLyEAVRE
0 153 Y11‑p KVSRDtLyEAVREVL
0 1 K45 LKNYDPQKDKRFSGT
0 20 K47 NYDPQKDKRFSGTVR
0 2 S50 PQKDKRFSGTVRLKS
0 2 K62‑ac LKSTPRPkFSVCVLG
0 1 K62‑ub LKSTPRPkFSVCVLG
0 35 K91‑ac HMDIEALkkLNKNKK
0 3 K91‑ub HMDIEALkkLNKNKK
0 1 K91‑sc HMDIEALkkLNKNKK
0 10 K92‑ac MDIEALkkLNKNKKL
0 8 K106‑ac LVKKLAKkyDAFLAS
0 5 K106‑ub LVKKLAKkyDAFLAS
0 1 K106‑sm LVKKLAKkyDAFLAS
0 1 Y107‑p VKKLAKkyDAFLASE
0 7 K118‑ac LASESLIkQIPRILG
0 7 K118‑ub LASESLIkQIPRILG
0 8 K130‑ub ILGPGLNkAGkFPSL
0 4 K133‑ub PGLNkAGkFPSLLTH
0 1 K133‑ac PGLNkAGkFPSLLTH
0 5 K152‑ub VAKVDEVkSTIKFQM
0 1 K152‑sc VAKVDEVkSTIKFQM
0 1 K207 NVRALYIKSTMGkPQ
0 1 S208 VRALYIKSTMGkPQR
0 2 K212‑ub YIKSTMGkPQRLy__
0 1 Y217‑p MGkPQRLy_______
  mouse

 
T9 SSKVSRDTLyEAVRE
Y11‑p KVSRDTLyEAVREVL
K45‑ac LKNYDPQkDkRFsGT
K47‑ac NYDPQkDkRFsGTVR
S50‑p PQkDkRFsGTVRLKS
K62 LKSTPRPKFSVCVLG
K62 LKSTPRPKFSVCVLG
K91‑ac HMDIEALkkLNKNKK
K91‑ub HMDIEALkkLNKNKK
K91‑sc HMDIEALkkLNKNKK
K92‑ac MDIEALkkLNKNKKL
K106‑ac LVKKLAKkYDAFLAS
K106‑ub LVKKLAKkYDAFLAS
K106 LVKKLAKKYDAFLAS
Y107 VKKLAKkYDAFLASE
K118‑ac LASESLIkQIPRILG
K118‑ub LASESLIkQIPRILG
K130‑ub ILGPGLNkAGKFPSL
K133 PGLNkAGKFPSLLTH
K133 PGLNkAGKFPSLLTH
K152‑ub VAKVDEVkSTIKFQM
K152 VAKVDEVKSTIKFQM
K207 NVRALYIKsTMGKPQ
S208‑p VRALYIKsTMGKPQR
K212 YIKsTMGKPQRLY__
Y217 MGKPQRLY_______
  rat

 
T9 SSKVSRDTLyEAVRE
Y11‑p KVSRDTLyEAVREVL
K45 LKNYDPQKDKRFSGT
K47 NYDPQKDKRFSGTVR
S50 PQKDKRFSGTVRLKS
K62 LKSTPRPKFSVCVLG
K62 LKSTPRPKFSVCVLG
K91‑ac HMDIEALkKLNKNKK
K91 HMDIEALKKLNKNKK
K91 HMDIEALKKLNKNKK
K92 MDIEALkKLNKNKKL
K106‑ac LVKKLAKkYDAFLAS
K106 LVKKLAKKYDAFLAS
K106 LVKKLAKKYDAFLAS
Y107 VKKLAKkYDAFLASE
K118‑ac LASESLIkQIPRILG
K118 LASESLIKQIPRILG
K130 ILGPGLNKAGKFPSL
K133 PGLNKAGKFPSLLTH
K133 PGLNKAGKFPSLLTH
K152 VAKVDEVKSTIKFQM
K152 VAKVDEVKSTIKFQM
K207‑ac NVRALYIkSTMGKPQ
S208 VRALYIkSTMGKPQR
K212 YIkSTMGKPQRLY__
Y217 MGKPQRLY_______
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