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Protein Page:
CD97 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD97 Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 2; Receptor, GPCR
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component: focal adhesion; integral to plasma membrane; membrane; plasma membrane
Molecular Function: protein binding; transmembrane receptor activity
Biological Process: cell motility; cell-cell signaling; immune response; inflammatory response
Reference #:  P48960 (UniProtKB)
Alt. Names/Synonyms: CD97; CD97 antigen; CD97 antigen subunit alpha; CD97 antigen subunit beta; CD97 molecule; Leukocyte antigen CD97; seven-span transmembrane protein; seven-transmembrane, heterodimeric receptor associated with inflammation; TM7LN1
Gene Symbols: ADGRE5
Molecular weight: 91,869 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
Select Structure to View Below

CD97

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T373‑p ERGDKNVtMGQssAR
0 1 S377‑p KNVtMGQssARMKLN
0 1 S378‑p NVtMGQssARMKLNW
0 1 E425 LHSKKQAELEEIyES
0 1 Y430‑p QAELEEIyESSIRGV
0 1 S531‑p TCQCSHLsSFAILMA
0 1 Y540‑p FAILMAHyDVEDWKL
0 2 K730‑ub SEINPDMkKLKKARA
0 2 K809‑ub CLVAGGSkysEFtst
0 4 Y810‑p LVAGGSkysEFtstt
0 1 S811‑p VAGGSkysEFtstts
0 1 T814‑p GSkysEFtsttsGtG
0 3 S815‑p SkysEFtsttsGtGH
0 3 T816‑p kysEFtsttsGtGHN
0 2 T817‑p ysEFtsttsGtGHNQ
0 5 S818‑p sEFtsttsGtGHNQt
0 3 T820‑p FtsttsGtGHNQtRA
0 2 N823 ttsGtGHNQtRALRA
0 5 T825‑p sGtGHNQtRALRAsE
0 2 A830 NQtRALRAsEsGI__
0 25 S831‑p QtRALRAsEsGI___
0 9 S833‑p RALRAsEsGI_____
  mouse

 
T371 EQDNKDVTTVHHGQT
G376 DVTTVHHGQTWMELD
Q377 VTTVHHGQTWMELDW
S425‑p NLEQRRAsLEDFYGS
Y430 RAsLEDFYGSPIPSV
T513 FCHCNHLTSFAILMA
Y522 FAILMAQYHVQDPRL
K714 SEINPNMKKLRKARV
K792 ACMVTGSKYTEFNSS
Y793 CMVTGSKYTEFNSST
T794 MVTGSKYTEFNSSTT
N797 GSKYTEFNSSTTGTG
S798 SKYTEFNSSTTGTGT
S799 KYTEFNSSTTGTGTs
T800 YTEFNSSTTGTGTsQ
T801 TEFNSSTTGTGTsQt
T803 FNSSTTGTGTsQtRA
S806‑p STTGTGTsQtRALRs
T808‑p TGTGTsQtRALRssE
S813‑p sQtRALRssEsGM__
S814‑p QtRALRssEsGM___
S816‑p RALRssEsGM_____
  rat

 
T378 EQDNKDVTTVHHSQA
S383 DVTTVHHSQAWMQLD
Q384 VTTVHHSQAWMQLDW
T432 NLEQKRDTLEDLYGS
Y437 RDTLEDLYGSPVQSV
T521 FCHCNHLTSFAVLMA
Y530 FAVLMAQYHVQDPRL
K721 SEINPNMKKLRKARV
K799 ACMVTGNKYTEFTSS
Y800 CMVTGNKYTEFTSST
T801 MVTGNKYTEFTSSTT
T804 GNKYTEFTSSTTGTG
S805 NKYTEFTSSTTGTGT
S806 KYTEFTSSTTGTGTS
T807 YTEFTSSTTGTGTSQ
T808 TEFTSSTTGTGTSQT
T810 FTSSTTGTGTSQTRT
S813 STTGTGTSQTRTLRP
T815 TGTGTSQTRTLRPsE
P820 SQTRTLRPsEsGM__
S821‑p QTRTLRPsEsGM___
S823‑p RTLRPsEsGM_____
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