Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
KCNE3 (human)

Overview
KCNE3 Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Belongs to the potassium channel KCNE family. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: cytoplasm; dendrite; lipid raft; perikaryon; plasma membrane; vesicle; voltage-gated potassium channel complex
Molecular Function: potassium channel regulator activity; protein binding; voltage-gated potassium channel activity
Disease: Brugada Syndrome 6
Reference #:  Q9Y6H6 (UniProtKB)
Alt. Names/Synonyms: cardiac voltage-gated potassium channel accessory subunit; DKFZp781H21101; HOKPP; HYPP; KCNE3; MGC102685; MGC129924; minimum potassium ion channel-related peptide 2; minK-related peptide 2; MiRP2; potassium channel subunit beta MiRP2; Potassium voltage-gated channel subfamily E member; potassium voltage-gated channel subfamily E member 3; potassium voltage-gated channel, Isk-related family, member 3; voltage-gated K+ channel subunit MIRP2
Gene Symbols: KCNE3
Molecular weight: 11,710 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
Select Structure to View Below

KCNE3

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
activity, induced: S82‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 S82‑p LILGYTRsRKVDKRS
0 1 Y92 VDKRSDPYHVYIKNR
0 1 Y95 RSDPYHVYIKNRVSM
  mouse

 
S82 LILGYTRSRKVDKRS
Y92‑p VDKRSDPyHVyIKNR
Y95‑p RSDPyHVyIKNRVSM
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.