Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: integral to plasma membrane; neuron projection; nucleus; plasma membrane
Molecular Function: nerve growth factor binding; transmembrane receptor activity; tumor necrosis factor receptor activity
Biological Process: axon guidance; immune response; inflammatory response; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway
Alt. Names/Synonyms: CD30; CD30 antigen; CD30L receptor; cytokine receptor CD30; D1S166E; Ki-1; Ki-1 antigen; Lymphocyte activation antigen CD30; TNFRSF8; TNR8; Tumor necrosis factor receptor superfamily member 8; tumor necrosis factor receptor superfamily, member 8
Gene Symbols: TNFRSF8
Basal Isoelectric point:
Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology
Select Structure to View Below
1D01 - G/H/I=576-583 (human)
Loading....... Please wait