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Protein Page:
TNFRSF8 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TNFRSF8 Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: cytoplasm; integral to plasma membrane
Molecular Function: transmembrane receptor activity; tumor necrosis factor receptor activity
Biological Process: immune response; inflammatory response; multicellular organismal development; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway
Reference #:  P28908 (UniProtKB)
Alt. Names/Synonyms: CD30; CD30 antigen; CD30L receptor; cytokine receptor CD30; D1S166E; Ki-1; Ki-1 antigen; Lymphocyte activation antigen CD30; TNFRSF8; TNR8; Tumor necrosis factor receptor superfamily member 8; tumor necrosis factor receptor superfamily, member 8
Gene Symbols: TNFRSF8
Molecular weight: 63,747 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Select Structure to View Below

TNFRSF8

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S206‑ga RLAQEAAsKLtRAPD
0 1 T209‑ga QEAAsKLtRAPDSPS
0 1 S222 PSSVGRPSSDPGLSP
0 1 K419‑ub CRKRIRQkLHLCYPV
0 1 S429‑p LCYPVQTsQPKLELV
0 1 S438‑p PKLELVDsRPRRsst
0 11 S443‑p VDsRPRRsstQLRsG
0 35 S444‑p DsRPRRsstQLRsGA
0 23 T445‑p sRPRRsstQLRsGAs
0 9 S449‑p RsstQLRsGAsVtEP
0 18 S452‑p tQLRsGAsVtEPVAE
0 1 T454‑p LRsGAsVtEPVAEER
0 5 Y479‑p CHSVGAAyLESLPLQ
0 1 S496‑p SPAGGPSsPRDLPEP
0 12 Y518‑p NNKIEKIyIMKADTV
0 1 Y560‑p EADHTPHyPEQETEP
  mouse

 
T203 NLVQEDATELVKVPE
V206 QEDATELVKVPESSS
S220‑p SSKAREPsPDPGNAE
K320 CRRRFQQKFHLDYLV
F330 LDYLVQTFQPKMEQT
S339 PKMEQTDSCPTEKLT
K344 TDSCPTEKLTQPQRs
L345 DSCPTEKLTQPQRsG
T346 SCPTEKLTQPQRsGs
S351‑p KLTQPQRsGsVTDPS
S353‑p TQPQRsGsVTDPSTG
T355 PQRsGsVTDPSTGHK
Y382 CASVGATYLENLPLL
S399 SPAGNPFSPREPPEP
Y421 NNRIEKIYIMKADTV
Y463 EVDHAPHYPEQETEP
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