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Protein Page:
LAMA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LAMA1 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Extracellular matrix
Chromosomal Location of Human Ortholog: 18p11.3
Cellular Component: basement membrane; extracellular matrix; extracellular region; extracellular space; laminin-1 complex; laminin-3 complex; proteinaceous extracellular matrix
Molecular Function: extracellular matrix structural constituent; protein binding; receptor binding
Biological Process: cell adhesion; cell surface receptor linked signal transduction; extracellular matrix organization and biogenesis; regulation of cell adhesion; regulation of cell migration; regulation of embryonic development
Disease: Poretti-boltshauser Syndrome
Reference #:  P25391 (UniProtKB)
Gene Symbols: LAMA1
Molecular weight: 337,084 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
Select Structure to View Below

LAMA1

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S31‑p PAILNLAsNAHISTN
0 1 Y163 DSECLSRYNITPRRG
0 1 T166 CLSRYNITPRRGPPT
0 2 Y337‑p HNKAKDCyYDESVAK
0 1 S348‑p SVAKQKKsLNtAGQF
0 1 T351‑p KQKKsLNtAGQFRGG
0 4 K486‑ac GKACDRCkPGFyNLK
0 1 Y490‑p DRCkPGFyNLKEKNP
0 1 S553‑p LGGRHQVsINNTAVM
0 1 T581‑p AYLGNKLtAFGGFLK
0 1 Y683‑p NSAKMALyRLESVSL
0 1 Y890‑p ERCADGFyGDAVtAK
0 1 T895‑p GFyGDAVtAKNCRAC
0 1 S1299‑p NFWKYFNsVSEKPVt
0 1 T1306‑p sVSEKPVtREDFMSV
0 1 T1426‑p CLNCGDNtAGDHCDV
0 1 S1436‑p DHCDVCTsGYyGKVT
0 1 Y1439‑p DVCTsGYyGKVTGSA
0 1 T1501‑p SYYGNPQtPGGSCQK
0 1 S1505 NPQtPGGSCQKCDCN
0 1 K1508 tPGGSCQKCDCNPHG
0 1 S1516 CDCNPHGSVHGDCDR
0 1 G1519 NPHGSVHGDCDRTSG
0 1 K1616‑ac NMQKDLGkIKLEGVA
0 2 K1953 QRSSRFLKEGNNLSR
0 1 T2187‑p WDLGSGStRLEFPDF
0 1 S2474‑p TFDLLRNsyGVRkGC
0 1 Y2475‑p FDLLRNsyGVRkGCL
0 1 K2479‑m1 RNsyGVRkGCLLEPI
0 1 S2508 PKSLSPESEWLVTFA
0 1 E2509 KSLSPESEWLVTFAT
0 1 T2516 EWLVTFATTNSSGII
0 1 S2615‑p KLGTLVEsRTINVSN
0 1 Y2753 FASSGLIYYMAHQNQ
0 1 Y2754 ASSGLIYYMAHQNQA
0 1 S2875‑p SKQLDKDsPVSAFTV
0 1 T2922‑p NITLEFRtSSQNGVL
0 1 S2933‑p NGVLLGIsTAKVDAI
0 1 S3048‑p RKLALIKsPQVQsFD
0 1 S3053‑p IKsPQVQsFDFSRAF
  mouse

 
T38 PAILNLATNAHISAN
Y170‑p DTECLTRyKItPRRG
T173‑p CLTRyKItPRRGPPT
Y344 HNKAKDCYYDSSVAK
S355 SVAKERRSLNTAGQY
T358 KERRSLNTAGQYSGG
K493‑ac GKNCDRCkPGFYNLK
Y497 DRCkPGFYNLKERNP
S560 LGGHRQISINNTAVM
T588 AYLGNKLTAFGGFLK
Y690 NSAKMALYRLDSVSL
Y897 ERCADGFYGDAVTAK
T902 GFYGDAVTAKNCRAC
S1306 EFWKYFNSVSEKHVT
T1313 SVSEKHVTHSDFMSV
T1433 CLSCRDHTSGDHCEL
S1443 DHCELCASGYYGKVT
Y1446 ELCASGYYGKVTGLP
A1508 GYHGNPRAAGGsCQt
S1512‑p NPRAAGGsCQtCDCN
T1515‑p AAGGsCQtCDCNPQG
S1523‑p CDCNPQGsVHsDCDR
S1526‑p NPQGsVHsDCDRASG
E1623 NAKKIRAEIQLEGIA
K1961‑ac QRSSRFLkESVGTRR
T2195 WDLGSGSTRLEFPEV
S2482 TFDLLRNSYGVRKGC
Y2483 FDLLRNSYGVRKGCA
K2487 RNSYGVRKGCALEPI
S2516‑p PKSLSPEssLLATFA
S2517‑p KSLSPEssLLATFAt
T2524‑p sLLATFAtKNSSGIL
G2622 KLGPLTEGKTIDISN
Y2762‑p FASSGLIyyVAHQNQ
Y2763‑p ASSGLIyyVAHQNQM
R2884 GQQLDKDRPLSASAV
T2931 NITLEFRTTSKNGVL
S2942 NGVLLGISSAKVDAI
G3057 RNLRLSRGSQVQSLD
S3062 SRGSQVQSLDLSRAF
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