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Protein Page:
FOXC1 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXC1 Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6p25
Cellular Component: cytoplasm; nuclear heterochromatin; nucleoplasm; nucleus
Molecular Function: DNA bending activity; DNA binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: artery morphogenesis; blood vessel remodeling; brain development; camera-type eye development; cardiac muscle cell proliferation; cell differentiation; cell migration; cell proliferation; collagen fibril organization; embryonic heart tube development; eye development; germ cell migration; glycosaminoglycan metabolic process; heart development; in utero embryonic development; lacrimal gland development; lymph vessel development; mesenchymal cell development; negative regulation of angiogenesis; negative regulation of mitotic cell cycle; neural crest cell development; Notch signaling pathway; odontogenesis of dentine-containing teeth; ossification; ovarian follicle development; paraxial mesoderm formation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of blood vessel size; regulation of organ growth; regulation of transcription, DNA-dependent; skeletal development; somitogenesis; transcription from RNA polymerase II promoter; ureteric bud development; vascular endothelial growth factor receptor signaling pathway; ventricular cardiac muscle morphogenesis
Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1
Reference #:  Q12948 (UniProtKB)
Alt. Names/Synonyms: ARA; FKHL7; forkhead box C1; Forkhead box protein C1; forkhead, drosophila, homolog-like 7; forkhead-related activator 3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7; FOXC1; FREAC-3; FREAC3; IGDA; IHG1; IRID1; myeloid factor-delta; RIEG3
Gene Symbols: FOXC1
Molecular weight: 56,789 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXC1

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S272‑p
activity, induced: S272‑p
protein stabilization: S272‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S8 MQARYSVSsPNsLGV
0 1 S9‑p QARYSVSsPNsLGVV
0 3 S12‑p YSVSsPNsLGVVPYL
1 10 T68‑p ARAYGPYtPQPQPKD
0 1 K181 FKKKDAVKDKEEKDR
0 5 T228‑p VRIQDIKtENGtCPs
0 4 T232‑p DIKtENGtCPsPPQP
0 15 S235‑p tENGtCPsPPQPLsP
0 18 S241‑p PsPPQPLsPAAALGS
0 1 S248 sPAAALGSGSAAAVP
1 1 S272‑p SSLSSGSsPPGSLPS
0 6 S320‑p IMTSLRGsPQsAAAE
0 1 S323‑p SLRGsPQsAAAELSs
0 1 S330‑p sAAAELSsGLLAsAA
0 1 S335‑p LSsGLLAsAAASSRA
0 4 S521‑p QRIGLNNsPVNGNSS
  mouse

 
S8‑p MQARYSVsSPNsLGV
S9 QARYSVsSPNsLGVV
S12‑p YSVsSPNsLGVVPYL
T68‑p ARAYGPYtPQPQPKD
K181‑ac FKKKDAVkDKEEKGR
T230‑p VRIQDIKtENGtCPs
T234‑p DIKtENGtCPsPPQP
S237‑p tENGtCPsPPQPLsP
S243‑p PsPPQPLsPAAALGs
S250‑p sPAAALGsGSAATVP
S274 SSLSSGSSPPGSLPS
S320 IMTSLRGSPQGSAAE
G323 SLRGSPQGSAAELGS
S330 GSAAELGSGLLASAA
S335 LGSGLLASAAASSRA
S521‑p QRIGLNNsPVNGNSS
  rat

 
S8 MQARYSVSSPNSLGV
S9 QARYSVSSPNSLGVV
S12 YSVSSPNSLGVVPYL
T68 ARAYGPYTPQPQPKD
K181 FKKKDAVKDKEEKGR
T230 VRIQDIKTENGTCPS
T234 DIKTENGTCPSPPQP
S237 TENGTCPSPPQPLSP
S243 PSPPQPLSPAAALGS
S250 SPAAALGSGSAATVP
S274 SSLSSGSSPPGSLPS
S320 IMTSLRGSPQGSAAE
G323 SLRGSPQGSAAELGS
S330 GSAAELGSGLLASAA
S335 LGSGLLASAAASSRA
S521 QRIGLNNSPVNGNSS
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