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Protein Page:
SSTR4 (human)

Overview
SSTR4 Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: 20p11.2
Cellular Component: integral to plasma membrane; neuron projection; plasma membrane
Molecular Function: neuropeptide binding
Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cell proliferation; synaptic transmission
Reference #:  P31391 (UniProtKB)
Alt. Names/Synonyms: somatostatin receptor 4; Somatostatin receptor type 4; SS-4-R; SS4-R; SS4R; SSR4; SSTR4
Gene Symbols: SSTR4
Molecular weight: 42,003 Da
Basal Isoelectric point: 9.09  Predict pI for various phosphorylation states
Select Structure to View Below

SSTR4

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T385‑p KRIPLTRtTTF____
  mouse

 
T382 KQVPFTKTTTF____
  rat

 
T381 KRVPFTKTTTF____
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