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NOXA
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Interacts with MCL1, BCL2A1 and BAX. Up-regulated by p53/TP53, phorbol esters, double- stranded RNA, IFNB1/IFN-beta and viruses. Highly expressed in adult T-cell leukemia cell line. Belongs to the PMAIP1 family. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Mitochondrial |
| Chromosomal Location of Human Ortholog: 18q21.32 |
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Cellular Component: cytosol; mitochondrial outer membrane; mitochondrion; nucleus
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Molecular Function: protein binding
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Biological Process: apoptosis; cellular response to glucose starvation; defense response to virus; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of protein oligomerization; proteasomal protein catabolic process; protein insertion into mitochondrial membrane during induction of apoptosis; regulation of apoptosis; regulation of mitochondrial membrane permeability; response to dsRNA; T cell homeostasis
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Reference #:
Q13794
(UniProtKB)
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Alt. Names/Synonyms: adult T cell leukemia-derived PMA-responsive; APR; Immediate-early-response protein APR; NOXA; Phorbol-12-myristate-13-acetate-induced protein 1; PMA-induced protein 1; PMAIP1; Protein Noxa
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Gene Symbols: PMAIP1
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Molecular weight:
6,030 Da
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Basal Isoelectric point:
10.3
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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Mitochondrial Control of Apoptosis
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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