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Protein Page:
TMEM43 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TMEM43 May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane. Defects in TMEM43 are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5); also known as arrhythmogenic right ventricular cardiomyopathy (ARVC5). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Belongs to the TMEM43 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3p25.1
Cellular Component: endoplasmic reticulum lumen; Golgi apparatus; integral to nuclear inner membrane
Molecular Function: protein binding; protein self-association
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 5; Emery-dreifuss Muscular Dystrophy 7, Autosomal Dominant
Reference #:  Q9BTV4 (UniProtKB)
Alt. Names/Synonyms: ARVC5; ARVD5; DKFZp586G1919; LUMA; MGC3222; Protein LUMA; TMEM43; TMM43; Transmembrane protein 43
Gene Symbols: TMEM43
Molecular weight: 44,876 Da
Basal Isoelectric point: 7.86  Predict pI for various phosphorylation states
Select Structure to View Below

TMEM43

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S20‑p EHVKVKTsSQPGFLE
0 1 T60‑p NEGRALKtATSLAEG
0 1 K99‑ub IGALRTSkLLsDPNY
0 1 S102‑p LRTSkLLsDPNYGVH
0 1 S193‑p QIGRFFLsSGLIDKV
0 1 S209‑p NFKSLSLsKLEDPHV
0 1 K232‑ub FYHSENPkyPEVGDL
0 5 Y233‑p YHSENPkyPEVGDLR
0 1 S244‑p GDLRVSFsYAGLsGD
0 1 S249‑p SFsYAGLsGDDPDLG
0 1 T282‑p FSTKSGDtLLLLHHG
0 1 S292‑p LLHHGDFsAEEVFHR
  mouse

 
E20 EHVKVTSEPQPGFLE
T60 NEGRALKTATSLAEG
K99 IGALRTSKLLSDPNY
S102 LRTSKLLSDPNYGVH
S193 QIGRFFLSAGLIDKI
A209 NFKALSLAKLEDPHV
K232 FYHSENPKYPEVGDV
Y233 YHSENPKYPEVGDVR
S244 GDVRVSFSYAGLSSD
S249 SFSYAGLSSDDPDLG
T282 YSTKSGDTLLLLHHG
S292 LLHHGDFSAEEVFRR
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