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Protein Page:
ECGF1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ECGF1 May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Note: This description may include information from UniProtKB.
Protein type: Phosphorylase; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - pyrimidine; Transferase; DNA replication; Motility/polarity/chemotaxis; Cytokine; EC 2.4.2.4
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: cytosol
Molecular Function: growth factor activity; phosphorylase activity; platelet-derived growth factor receptor binding; pyrimidine-nucleoside phosphorylase activity; thymidine phosphorylase activity; transferase activity, transferring pentosyl groups
Biological Process: angiogenesis; cell differentiation; chemotaxis; DNA replication; mitochondrial genome maintenance; pyrimidine base metabolic process; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage; pyrimidine nucleotide metabolic process
Disease: Mitochondrial Dna Depletion Syndrome 1 (mngie Type)
Reference #:  P19971 (UniProtKB)
Alt. Names/Synonyms: ECGF1; endothelial cell growth factor 1 (platelet-derived); Gliostatin; hPD-ECGF; MNGIE; PD-ECGF; PDECGF; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine phosphorylase; TP; TYMP; TYPH
Gene Symbols: TYMP
Molecular weight: 49,955 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ECGF1

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T6‑p __MAALMtPGTGAPP
0 1 T9 AALMtPGTGAPPAPG
0 1 S19‑p PPAPGDFsGEGsQGL
0 1 S23‑p GDFsGEGsQGLPDPS
0 6 S50‑p KRDGGRLsEADIRGF
0 1 K115 WRQQLVDKHSTGGVG
0 1 K221 ITASILSKKLVEGLS
0 1 T271‑p LRVAAALtAMDkPLG
0 1 K275‑ac AALtAMDkPLGRCVG
0 1 S364 ARALCSGSPAERRQL
0 1 Q482 ELVLPPQQ_______
  ECGF1 iso2  
T6 __MAALMTPGTGAPP
T9 AALMTPGTGAPPAPG
S19 PPAPGDFSGEGSQGL
S23 GDFSGEGSQGLPDPS
S50 KRDGGRLSEADIRGF
K115 WRQQLVDKHSTGGVG
K221 ITASILSKKLVEGLS
T271 LRVAAALTAMDKPLG
K275 AALTAMDKPLGRCVG
S364 ARALCSGSPAERRQL
Q487 ELVLPPQQ_______
  mouse

 
A3 _____MAAPGTPPPS
T6 __MAAPGTPPPSASG
- gap
- gap
R36 KRDGGHLREADIRNF
K101‑ub WHQQLVDkHSTGGVG
K207‑ub ITASILSkKAVEGLS
T257 LKVAAALTAMDNPLG
N261 AALTAMDNPLGRSVG
S350 AKALCSGSPTQRRQL
I468 ELVLPPTIAQP____
  rat

 
A3 _____MAAPGtPPPL
T6‑p __MAAPGtPPPLAPE
- gap
- gap
S43 KRNGGHLSEADIRNF
K108 WHQQLVDKHSTGGVG
K214 ITASILSKKAVEGLS
T264 LQVAAALTAMDNPLG
N268 AALTAMDNPLGRNVG
S357‑p ARALCSGsPTQRRQL
T475‑p ELVLPPTtP______
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