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Protein Page:
COL18A1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
COL18A1 COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1). An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele. Belongs to the multiplexin collagen family. 3 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: endoplasmic reticulum lumen; extracellular matrix; extracellular region; extracellular space
Biological Process: collagen catabolic process; extracellular matrix organization and biogenesis; negative regulation of cell proliferation; organ morphogenesis; visual perception
Disease: Knobloch Syndrome 1
Reference #:  P39060 (UniProtKB)
Alt. Names/Synonyms: antiangiogenic agent; COIA1; COL18A1; Collagen alpha-1(XVIII) chain; collagen, type XVIII, alpha 1; Endostatin; FLJ27325; FLJ34914; KNO; KNO1; MGC74745; multi-functional protein MFP
Gene Symbols: COL18A1
Molecular weight: 178,188 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Select Structure to View Below

COL18A1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T93‑p LLEDGQDtPTSAEsP
0 1 S99‑p DtPTSAEsPDAPEEN
0 1 T696‑p LPAPPPVttPPLAGG
0 1 T697‑p PAPPPVttPPLAGGs
0 1 S704‑p tPPLAGGsstEDsRs
0 1 S705‑p PPLAGGsstEDsRsE
0 1 T706‑p PLAGGsstEDsRsEE
0 1 S709‑p GGsstEDsRsEEVEE
0 1 S711‑p sstEDsRsEEVEEQT
0 1 Y1211‑p FRGPPGPyGRPGYKG
0 2 S1245‑p KGEPGDAsLGFGMRG
0 1 T1450‑p SGVRLWAtRQAMLGQ
0 1 T1527‑ga RREHPHPtARPWRAD
0 1 S1539‑ga RADDILAsPPRLPEP
0 1 S1588‑p LHLVALNsPLSGGMR
0 1 K1666‑ub SGSEGPLkPGARIFS
  mouse

 
V113 GSPATPAVPIPLVAP
S123 PLVAPAASPDMKEEN
T730 LPQPPPVTSPPLAGG
S731 PQPPPVTSPPLAGGS
S738 SPPLAGGSTTEDPRT
T739 PPLAGGSTTEDPRTE
T740 PLAGGSTTEDPRTEE
P743 GGSTTEDPRTEETEE
T745 STTEDPRTEETEEDA
Y1232 FRGPPGPYGRPGHKG
S1266 KGEPGDASLGFSMRG
T1468 GQVRIWATYQTMLDK
T1545 RREYSYSTARPWRAD
N1557 RADDILANPPRLPDR
T1607 LHLVALNTPLSGGMR
Q1685 SGSQGQLQPGARIFS
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