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Protein Page:
AGXT (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AGXT Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - glycine, serine and threonine; EC 2.6.1.44; Mitochondrial; EC 2.6.1.51; Motility/polarity/chemotaxis; Transferase
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: peroxisomal matrix; peroxisome
Molecular Function: alanine-glyoxylate transaminase activity; amino acid binding; protein binding; protein homodimerization activity; protein self-association; pyridoxal phosphate binding; receptor binding; serine-pyruvate transaminase activity; transaminase activity
Biological Process: glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; L-alanine catabolic process; L-cysteine catabolic process; proteasomal protein catabolic process
Disease: Hyperoxaluria, Primary, Type I
Reference #:  P21549 (UniProtKB)
Alt. Names/Synonyms: AGT; AGT1; AGXT; AGXT1; Alanine--glyoxylate aminotransferase; alanine-glyoxylate aminotransferase; hepatic peroxisomal alanine:glyoxylate aminotransferase; L-alanine: glyoxylate aminotransferase 1; PH1; Serine--pyruvate aminotransferase; serine-pyruvate aminotransferase; serine:pyruvate aminotransferase; SPAT; SPT; SPYA; TLH6
Gene Symbols: AGXT
Molecular weight: 43,010 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Select Structure to View Below

AGXT

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T9‑p ASHKLLVtPPKALLK
0 2 K16 tPPKALLKPLSIPNQ
0 1 N22 LKPLSIPNQLLLGPG
0 3 G42 PRIMAAGGLQMIGSM
0 2 K51 QMIGSMSKDMYQIMD
0 1 S81‑p LTLVISGsGHCALEA
0 9 Y194‑p SLGGTPLyMDRQGID
0 1 K225 SLISFSDKAKkKMyS
0 1 K225 SLISFSDKAKkKMyS
0 1 K225 SLISFSDKAKkKMyS
0 1 K227 ISFSDKAKkKMySRK
0 1 K228‑m3 SFSDKAKkKMySRKT
0 1 Y231‑p DKAKkKMySRKTKPF
0 2 K236 KMySRKTKPFSFYLD
0 1 K236 KMySRKTKPFSFYLD
0 1 W246 SFYLDIKWLANFWGC
0 2 Y260‑p CDDQPRMyHHTIPVI
0 1 S275 SLYSLRESLALIAEQ
0 21 Y297‑p QHREAAAyLHGRLQA
0 2 Q308 RLQALGLQLFVKDPA
0 2 Q308 RLQALGLQLFVKDPA
0 15 K312 LGLQLFVKDPALRLP
0 1 K312 LGLQLFVKDPALRLP
0 2 K312 LGLQLFVKDPALRLP
0 2 K389‑ac AALQHCPkKKL____
  mouse

 
P31 GSYQLLVPPPEALSk
K38‑ac PPPEALSkPLSVPTR
T44 SkPLSVPTRLLLGPG
S64‑p PRVLAAGsLRMIGHM
K73‑ac RMIGHMQkEMLQIME
S103 LTLVVSGSGHCAMET
Y216 SLGGVPIYMDQQGID
K247‑ac SLISFNDkAkYKVYS
K247‑ub SLISFNDkAkYKVYS
K247‑sc SLISFNDkAkYKVYS
K249‑sc ISFNDkAkYKVYSRK
Y250 SFNDkAkYKVYSRKT
Y253 DkAkYKVYSRKTkPV
K258‑ac KVYSRKTkPVSFYTD
K258‑ub KVYSRKTkPVSFYTD
Y268‑p SFYTDITyLAKLWGC
I282 CEGETRVIHHTTPVT
S297‑p SLYCLREsLALIAEQ
H319 RHREATAHLHKHLQE
K330‑ac HLQEMGLkFFVkDPE
K330‑sc HLQEMGLkFFVkDPE
K334‑ac MGLkFFVkDPEIRLP
K334‑ub MGLkFFVkDPEIRLP
K334‑sc MGLkFFVkDPEIRLP
K411 EALQHCPKNKL____
  rat

 
P31 GSHQLLVPPPEALSk
K38‑ac PPPEALSkPLSIPkR
K44‑ac SkPLSIPkRLLLGPG
S64 PRVLAAGSLRMIGHM
K73‑ac RMIGHMQkEMFQIMD
S103 LTLVVSGSGHCAMET
Y216 SLGGVPIYMDQQGID
K247 SLISFNDKAKSKVYS
K247 SLISFNDKAKSKVYS
K247 SLISFNDKAKSKVYS
K249 ISFNDKAKSKVYSRK
S250 SFNDKAKSKVYSRKT
Y253 DKAKSKVYSRKTkPV
K258‑ac KVYSRKTkPVSFYTD
K258 KVYSRKTKPVSFYTD
Y268 SFYTDITYLSKLWGC
I282 CEGKTRVIHHTLPVI
S297 SLYCLRESLALISEQ
H319 RHREATAHLHKCLRE
K330‑ac CLRELGLkFFVkDPE
K330 CLRELGLKFFVkDPE
K334‑ac LGLkFFVkDPEIRLP
K334 LGLkFFVKDPEIRLP
K334 LGLkFFVKDPEIRLP
K411 EALQHCPKNKL____
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