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Protein Page:
VLDLR (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VLDLR Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1); also known as dysequilibrium syndrome (DES) or non- progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9p24
Cellular Component: apical part of cell; cell surface; coated pit; integral to membrane; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; receptor complex
Molecular Function: apolipoprotein binding; calcium ion binding; calcium-dependent protein binding; glycoprotein binding; low-density lipoprotein receptor activity; protein binding; very-low-density lipoprotein binding; very-low-density lipoprotein receptor activity
Biological Process: cellular response to glucose starvation; cellular response to insulin stimulus; cerebral cortex development; cholesterol metabolic process; dendrite morphogenesis; heart development; lipid transport; memory; negative regulation of transcription from RNA polymerase II promoter; nervous system development; positive regulation of protein kinase activity; receptor-mediated endocytosis; response to drug; response to nutrient; signal transduction; ventral spinal cord development
Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1
Reference #:  P98155 (UniProtKB)
Alt. Names/Synonyms: CARMQ1; CHRMQ1; FLJ35024; very low density lipoprotein receptor; Very low-density lipoprotein receptor; VLDL receptor; VLDL-R; VLDLR; VLDLRCH
Gene Symbols: VLDLR
Molecular weight: 96,098 Da
Basal Isoelectric point: 4.62  Predict pI for various phosphorylation states
Select Structure to View Below

VLDLR

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T71‑ga EKNCVKKtCAESDFV
0 1 T277‑ga EVNCPSRtCRPDQFE
0 1 Y524‑p AIAVDWVyKTIYWTD
0 1 T541 SKTISVATLDGTKRK
0 1 S759‑p TATTVTYsETKDTNT
0 2 K828‑ub NWQHKNMkSMNFDNP
0 26 Y837‑p MNFDNPVyLkTTEED
0 10 K839‑ub FDNPVyLkTTEEDLs
0 1 S846‑p kTTEEDLsIDIGRHS
0 1 Y860‑p SASVGHTyPAISVVs
0 2 S867‑p yPAISVVstDDDLA_
0 2 T868‑p PAISVVstDDDLA__
  mouse

 
T71 EKNCVKKTCAESDFV
T277 EVNCPSRTCRPDQFE
Y524 AIAVDWVYKTIYWTD
T541‑p SKTISVAtLDGAKRK
S759 TSTPVTYSETKDINT
K828‑ub NWQHKNMkSMNFDNP
Y837 MNFDNPVYLkTTEED
K839‑ub FDNPVYLkTTEEDLS
S846 kTTEEDLSIDIGRHS
Y860 SASVGHTYPAISVVs
S867‑p YPAISVVstDDDLA_
T868‑p PAISVVstDDDLA__
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