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Protein Page:
ANXA1 (human)

ANXA1 a calcium/phospholipid-binding protein with which promotes membrane fusion and is involved in endocytosis. Has anti-inflammatory properties and inhibits phospholipase A2 activity. Accumulates on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation. Phosphorylated by PKC, EGFR and Chak1. Phosphorylation results in loss of the inhibitory activity. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Lipid-binding
Chromosomal Location of Human Ortholog: 9q21.13
Cellular Component: apical plasma membrane; cell surface; cell-cell adherens junction; cornified envelope; cytoplasm; early endosome membrane; endosome; extracellular region; extracellular space; extrinsic to external side of plasma membrane; extrinsic to membrane; focal adhesion; lateral plasma membrane; nucleoplasm; nucleus; plasma membrane; vesicle
Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; phospholipase A2 inhibitor activity; phospholipid binding; protein binding; protein binding, bridging; receptor binding; structural molecule activity
Biological Process: actin cytoskeleton reorganization; alpha-beta T cell differentiation; G-protein signaling, coupled to cyclic nucleotide second messenger; inflammatory response; keratinocyte differentiation; monocyte chemotaxis; negative regulation of apoptosis; negative regulation of exocytosis; negative regulation of T-helper 2 cell differentiation; neutrophil homeostasis; peptide cross-linking; phagocytosis; positive regulation of interleukin-2 production; positive regulation of T cell proliferation; positive regulation of T-helper 1 cell differentiation; positive regulation of vesicle fusion; regulation of cell shape; regulation of hormone secretion; regulation of inflammatory response; regulation of interleukin-1 production; regulation of leukocyte migration; signal transduction
Reference #:  P04083 (UniProtKB)
Alt. Names/Synonyms: Annexin A1; Annexin I; annexin I (lipocortin I); Annexin-1; ANX1; anxa 1; ANXA1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; LPC1; p35; Phospholipase A2 inhibitory protein
Gene Symbols: ANXA1
Molecular weight: 38,714 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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