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Protein Page:
FGFR4 (human)

Overview
FGFR4 a tyrosine-kinase receptor that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of the MAP kinase and AKT signaling pathways. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. Two isoforms of the human protein are formed by alternative splicing. This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; FGFR family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 5q35.2
Cellular Component: cytoplasm; endoplasmic reticulum; Golgi apparatus; integral to plasma membrane; intercellular junction; nucleoplasm; plasma membrane; transport vesicle
Molecular Function: 1-phosphatidylinositol-3-kinase activity; fibroblast growth factor binding; fibroblast growth factor receptor activity; heparin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: cell migration; fibroblast growth factor receptor signaling pathway; glucose homeostasis; MAPKKK cascade; peptidyl-tyrosine phosphorylation; phosphate ion homeostasis; phosphoinositide-mediated signaling; positive regulation of catalytic activity; positive regulation of cell proliferation; positive regulation of proteolysis; protein amino acid autophosphorylation; regulation of lipid metabolic process; regulation of phosphoinositide 3-kinase cascade
Reference #:  P22455 (UniProtKB)
Alt. Names/Synonyms: CD334; FGFR-4; FGFR4; Fibroblast growth factor receptor 4; JTK2; MGC20292; TKF; tyrosine kinase related to fibroblast growth factor receptor
Gene Symbols: FGFR4
Molecular weight: 87,954 Da
Basal Isoelectric point: 6.36  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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FGFR4

Protein Structure Not Found.
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