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Protein Page:
HAND1 (human)

Overview
HAND1 Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box). Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor; Cell development/differentiation; Nucleolus
Chromosomal Location of Human Ortholog: 5q33
Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus
Molecular Function: bHLH transcription factor binding; enzyme binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription coactivator activity; transcription corepressor activity; transcription factor binding
Biological Process: angiogenesis; blastocyst development; embryonic heart tube development; heart development; heart looping; mesoderm formation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; odontogenesis of dentine-containing teeth; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; trophectodermal cell differentiation; ventricular cardiac muscle morphogenesis
Reference #:  O96004 (UniProtKB)
Alt. Names/Synonyms: BHLHA27; Class A basic helix-loop-helix protein 27; EHAND; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; HAND1; heart and neural crest derivatives expressed 1; Heart- and neural crest derivatives-expressed protein 1; Hxt; Thing1
Gene Symbols: HAND1
Molecular weight: 23,627 Da
Basal Isoelectric point: 9.69  Predict pI for various phosphorylation states
Select Structure to View Below

HAND1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S98‑p RLGRRKGsGPKKERR
1 0 T107 PKKERRRTESINSAF
1 0 S109 KERRRTESINSAFAE
  mouse

 
S98 RLPKRKGSGPKKERR
T107‑p PKKERRRtEsINSAF
S109‑p KERRRtEsINSAFAE
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