Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box). Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Nucleolus; Transcription factor
Alt. Names/Synonyms: BHLHA27; Class A basic helix-loop-helix protein 27; EHAND; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; HAND1; heart and neural crest derivatives expressed 1; Heart- and neural crest derivatives-expressed protein 1; Hxt; Thing1