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Protein Page:
UPP1 (human)

UPP1 Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleotide Metabolism - pyrimidine; Transferase; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of Human Ortholog: 7p12.3
Cellular Component: cytosol
Molecular Function: uridine phosphorylase activity
Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage
Reference #:  Q16831 (UniProtKB)
Alt. Names/Synonyms: UDRPASE; UP; UPASE; UPase 1; UPP; UPP1; UrdPase 1; Uridine phosphorylase 1
Gene Symbols: UPP1
Molecular weight: 33,934 Da
Basal Isoelectric point: 8.17  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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