Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
H2AE (human)

Overview
H2AE Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6p22.1
Cellular Component: nuclear chromatin; nucleus
Molecular Function: DNA binding; enzyme binding; protein binding
Biological Process: chromatin silencing
Reference #:  Q99878 (UniProtKB)
Alt. Names/Synonyms: H2A histone family, member D; H2A.1; H2A/d; H2A1J; H2AFD; H2AFE; HIST1H2AG; HIST1H2AJ; HIST1H2AK; HIST1H2AL; HIST1H2AM; histone 1, H2ak; histone cluster 1, H2ak; histone H2A type 1; Histone H2A type 1-J; Histone H2A/e; histone H2A/p
Gene Symbols: HIST1H2AK
Molecular weight: 13,936 Da
Basal Isoelectric point: 10.88  Predict pI for various phosphorylation states
Select Structure to View Below

H2AE

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene