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Protein Page:
MLPH (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MLPH Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. Defects in MLPH are a cause of Griscelli syndrome type 3 (GS3). GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: dendrite; perinuclear region of cytoplasm
Molecular Function: metal ion binding; protein binding; Rab GTPase binding
Biological Process: intracellular protein transport
Disease: Griscelli Syndrome, Type 3
Reference #:  Q9BV36 (UniProtKB)
Gene Symbols: MLPH
Molecular weight: 65,949 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
Select Structure to View Below

MLPH

Protein Structure Not Found.
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Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 K136‑ub FKRFGSAkVIRSLHG
0 1 S155‑p GAGPELIsEERsGDs
0 1 S159‑p ELIsEERsGDsDQtD
0 3 S162‑p sEERsGDsDQtDEDG
0 5 T165‑p RsGDsDQtDEDGEPG
0 1 S173‑p DEDGEPGsEAQAQAQ
0 1 K185‑ac QAQPFGSkKKRLLsV
0 2 S191‑p SkKKRLLsVHDFDFE
0 2 S201‑p DFDFEGDsDDSTQPQ
0 2 S223‑p SVPEARDsPQsLtDE
0 2 S226‑p EARDsPQsLtDEsCS
0 2 T228‑p RDsPQsLtDEsCSEK
0 2 S231‑p PQsLtDEsCSEKAAP
0 1 H257 GASGCHSHPEEQPTS
0 1 S264 HPEEQPTSISPSRHG
0 1 S268 QPTSISPSRHGALAE
0 1 C277 HGALAELCPPGGSHR
0 1 M285 PPGGSHRMALGTAAA
0 6 T313‑p QYLADVDtsDEEsIR
0 7 S314‑p YLADVDtsDEEsIRA
0 1 S318‑p VDtsDEEsIRAHVMA
0 9 S336‑p SKRRGRAssESQIFE
0 16 S337‑p KRRGRAssESQIFEL
0 1 S397‑p EELTSNVsDQEtssE
0 1 T401‑p SNVsDQEtssEEEEA
0 1 S402‑p NVsDQEtssEEEEAK
0 1 S403‑p VsDQEtssEEEEAKD
0 1 S420‑p AEPNRDKsVGPLPQA
0 2 S444‑p QTNRQEKsPQDPGDP
0 4 Y454‑p DPGDPVQyNRttDEE
0 1 N455 PGDPVQyNRttDEEL
0 3 T457‑p DPVQyNRttDEELsE
0 6 T458‑p PVQyNRttDEELsEL
0 6 S463‑p RttDEELsELEDRVA
0 3 S481‑p SEVQQAEsEVsDIES
0 4 S484‑p QQAEsEVsDIESRIA
0 3 S510‑p SGKPRRKsNLPIFLP
0 1 D529 KLGKRPEDPNADPSS
0 10 S552‑p YLLRRKFsNsLKSQG
0 3 S554‑p LRRKFsNsLKSQGkD
0 1 S557 KFsNsLKSQGkDDDS
0 1 K560‑ub NsLKSQGkDDDSFDR
0 1 S564 SQGkDDDSFDRKsVY
0 1 S569‑p DDSFDRKsVYRGsLT
0 2 S574‑p RKsVYRGsLTQRNPN
  MLPH iso2  
K136 FKRFGSAKVIRSLHG
S155 GAGPELISEERSGDS
S159 ELISEERSGDSDQTD
S162 SEERSGDSDQTDEDG
T165 RSGDSDQTDEDGEPG
S173 DEDGEPGSEAQAQAQ
K185 QAQPFGSKKKRLLSV
S191 SKKKRLLSVHDFDFE
S201 DFDFEGDSDDSTQPQ
S223 SVPEARDSPQSLTDE
S226 EARDSPQSLTDESCS
T228 RDSPQSLTDESCSEK
S231 PQSLTDESCSEKAAP
H257 GASGCHSHPEEQPTS
S264 HPEEQPTSISPSRHG
S268 QPTSISPSRHGALAE
C277 HGALAELCPPGGSHR
M285 PPGGSHRMALGTAAA
T313 QYLADVDTSDEESIR
S314 YLADVDTSDEESIRA
S318 VDTSDEESIRAHVMA
S336‑p SKRRGRAssESQGLG
S337‑p KRRGRAssESQGLGA
S369 EELTSNVSDQETSSE
T373 SNVSDQETSSEEEEA
S374 NVSDQETSSEEEEAK
S375 VSDQETSSEEEEAKD
S392 AEPNRDKSVGPLPQA
S416 QTNRQEKSPQDPGDP
Y426 DPGDPVQYNRTTDEE
N427 PGDPVQYNRTTDEEL
T429 DPVQYNRTTDEELSE
T430 PVQYNRTTDEELSEL
S435 RTTDEELSELEDRVA
S453 SEVQQAESEVSDIES
S456 QQAESEVSDIESRIA
S482 SGKPRRKSNLPIFLP
D501 KLGKRPEDPNADPSS
S524‑p YLLRRKFsNSLKSQG
S526 LRRKFsNSLKSQGKD
S529 KFsNSLKSQGKDDDS
K532 NSLKSQGKDDDSFDR
S536 SQGKDDDSFDRKSVY
S541 DDSFDRKSVYRGSLT
S546 RKSVYRGSLTQRNPN
  mouse

 
K136 FKRFGSAKVIRSLCG
L155 GGGSEPSLEEGNGDs
N159 EPSLEEGNGDsEQtD
S162‑p LEEGNGDsEQtDEDG
T165‑p GNGDsEQtDEDGDLD
T173 DEDGDLDTEARDQPL
K183 RDQPLNSKKKKRLLS
S190 KKKKRLLSFRDVDFE
S200 DVDFEEDSDHLVQPC
S222 SVPESAHSLQSLSGE
S225 ESAHSLQSLSGEPYS
S227 AHSLQSLSGEPYSED
P230 LQSLSGEPYSEDTTS
S256‑p RALGCRPsPEVQPCs
S263‑p sPEVQPCsPLPsGED
S267‑p QPCsPLPsGEDAHAE
S277‑p DAHAELDsPAASCKs
S284‑p sPAASCKsAFGTTAM
T312‑p QYLADVDtsDEDSIQ
S313‑p YLADVDtsDEDSIQG
S317 VDtsDEDSIQGPRAA
V335 SKRRARTVPETQILE
P336 KRRARTVPETQILEL
S396 EELTSNISGSSTSSE
T400 SNISGSSTSSEDETK
S401 NISGSSTSSEDETKP
S402 ISGSSTSSEDETKPD
- gap
N432 HMETQERNPRSPGNP
P442 SPGNPARPtKstDEE
T443‑p PGNPARPtKstDEEL
S445‑p NPARPtKstDEELsE
T446‑p PARPtKstDEELsEM
S451‑p KstDEELsEMEDRVA
S469‑p SEVQQAEsEIsDIES
S472‑p QQAEsEIsDIESRIA
S498‑p SGKPRRKsGIPIFLP
T517‑p KLDRIPKtPPADPDD
S544‑p SLLRRKYsPSsQGVD
S546 LRRKYsPSsQGVDSG
S547‑p RRKYsPSsQGVDSGs
V550 YsPSsQGVDSGsFDR
S554‑p sQGVDSGsFDRKSVY
S559 SGsFDRKSVYRGsLT
S564‑p RKSVYRGsLTQRNPN
  rat

 
K136 FKRFGSAKVIRSLCG
L155 GGGSEPSLEEGNGDs
N159 EPSLEEGNGDsEQtD
S162‑p LEEGNGDsEQtDEDG
T165‑p GNGDsEQtDEDGELD
T173 DEDGELDTKAKDQSL
K183 KDQSLNSKKKRLLSF
S189 SKKKRLLSFRDVDFE
S199 DVDFEEDSDHSIQPC
S221 SVPESAQSLQSLSGE
S224 ESAQSLQSLSGEPYS
S226 AQSLQSLSGEPYSED
P229 LQSLSGEPYSEDTTS
S255 GASGCYPSPEEQPYS
S262 SPEEQPYSPLPSGED
S266 QPYSPLPSGEDAHTE
S276 DAHTELHSPATSCKS
S283 SPATSCKSTFGTTAM
T311‑p QYLADVDtsDEDSIP
S312‑p YLADVDtsDEDSIPG
S316 VDtsDEDSIPGPRAA
V334 TKRRARTVPETQISE
P335 KRRARTVPETQISEL
S395 EELTSNVSGSEISSE
I399 SNVSGSEISSEDETK
S400 NVSGSEISSEDETKP
S401 VSGSEISSEDETKPD
- gap
S431 HMEAQERSPRSPGNP
P441 SPGNPAQPTKstDEE
T442 PGNPAQPTKstDEEL
S444‑p NPAQPTKstDEELsE
T445‑p PAQPTKstDEELsEM
S450‑p KstDEELsEMEDRVA
S468 SEVQQAESEVSDIES
S471 QQAESEVSDIESRIA
S497 SGKPRRRSGIPIFLP
T516 KLDRIPKTPPADPEN
S542 CLMRRKYSPSSQGID
S544 MRRKYSPSSQGIDGG
S545 RRKYSPSSQGIDGGS
I548 YSPSSQGIDGGSFDR
S552 SQGIDGGSFDRKSVY
S557 GGSFDRKSVYRGSLT
S562 RKSVYRGSLTQRNPN
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