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Protein Page:
THPO (human)

Overview
THPO Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Cytokine; Cell cycle regulation; Secreted
Chromosomal Location of Human Ortholog: 3q27
Cellular Component: extracellular space
Molecular Function: cytokine activity; growth factor activity; hormone activity
Biological Process: blood coagulation; cell proliferation; multicellular organismal development; myeloid cell differentiation; platelet activation; positive regulation of megakaryocyte differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade
Disease: Thrombocythemia 1
Reference #:  P40225 (UniProtKB)
Alt. Names/Synonyms: C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; megakaryocyte stimulating factor; MGC163194; MGDF; MKCSF; ML; MPL ligand; MPLLG; Myeloproliferative leukemia virus oncogene ligand; THPO; Thrombopoietin; thrombopoietin nirs variant 1; TPO
Gene Symbols: THPO
Molecular weight: 37,823 Da
Basal Isoelectric point: 9.54  Predict pI for various phosphorylation states
Select Structure to View Below

THPO

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S34‑p ACDLRVLsKLLRDSH
0 1 H41 sKLLRDSHVLHSRLS
0 1 T58‑p PEVHPLPtPVLLPAV
0 1 S68‑p LLPAVDFsLGEWKTQ
0 1 T79‑p WKTQMEEtKAQDILG
0 1 T205‑p RTSGLLEtNFTASAR
0 1 S216‑p ASARTTGsGLLKWQQ
  mouse

 
N34 ACDPRLLNKLLRDSH
H41 NKLLRDSHLLHSRLS
I58 PDVDPLSIPVLLPAV
S68 LLPAVDFSLGEWKTQ
S79 WKTQTEQSKAQDILG
T205 RTSGLLETNFSVTAR
P216 VTARTAGPGLLSRLQ
  rat

 
N34 ACDPRLLNKLLRDSy
Y41‑p NKLLRDSyLLHSRLS
I58 PDVNPLSIPVLLPAV
S68 LLPAVDFSLGEWKTQ
S79 WKTQTEQSKAQDILG
T205 RTSGLLETNFSVVAR
P216 VVARTAGPGLLNRLQ
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