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Protein Page:
THPO (human)

Overview
THPO Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q27
Molecular Function: growth factor activity
Biological Process: multicellular organismal development; positive regulation of megakaryocyte differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade
Disease: Thrombocythemia 1
Reference #:  P40225 (UniProtKB)
Alt. Names/Synonyms: C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; megakaryocyte stimulating factor; MGC163194; MGDF; MKCSF; ML; MPL ligand; MPLLG; Myeloproliferative leukemia virus oncogene ligand; THPO; Thrombopoietin; thrombopoietin nirs variant 1; TPO
Gene Symbols: THPO
Molecular weight: 37,823 Da
Basal Isoelectric point: 9.54  Predict pI for various phosphorylation states
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THPO

Protein Structure Not Found.
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