Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
K3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

K3 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K12. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: keratin filament
Molecular Function: structural molecule activity
Biological Process: epithelial cell differentiation; intermediate filament cytoskeleton organization and biogenesis
Disease: Corneal Dystrophy, Meesmann
Reference #:  P12035 (UniProtKB)
Alt. Names/Synonyms: 65 kDa cytokeratin; CK-3; CK3; cytokeratin 3; Cytokeratin-3; FLJ95909; K2C3; K3; keratin 3; Keratin, type II cytoskeletal 3; Keratin-3; KRT3; Type-II keratin Kb3
Gene Symbols: KRT3
Molecular weight: 64,417 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


0 3 K203‑ub AQEREQIktLNNkFA
0 1 T204‑p QEREQIktLNNkFAs
0 30 K208‑ac QIktLNNkFAsFIDk
0 8 K208‑ub QIktLNNkFAsFIDk
0 2 K208‑sm QIktLNNkFAsFIDk
0 25 S211‑p tLNNkFAsFIDkVRF
0 6 K215‑ac kFAsFIDkVRFLEQQ
0 8 K215‑ub kFAsFIDkVRFLEQQ
0 1 S605‑p GVSGGGFssAsNRGG
0 1 S606‑p VSGGGFssAsNRGGs
0 1 S608‑p GGGFssAsNRGGsIK
0 1 S613‑p sAsNRGGsIKFSQSS
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.