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Protein Page:
SPTA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SPTA1 Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Defects in SPTA1 are the cause of elliptocytosis type 2 (EL2). EL2 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in SPTA1 are a cause of hereditary pyropoikilocytosis (HPP). HPP is an autosomal recessive disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells. Defects in SPTA1 are the cause of spherocytosis type 3 (SPH3); also known as hereditary spherocytosis type 3 (HS3). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive. Belongs to the spectrin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: actin cytoskeleton; cytosol
Molecular Function: actin filament binding; protein binding; Ras guanyl-nucleotide exchange factor activity; structural constituent of cytoskeleton
Biological Process: actin filament organization; axon guidance; ER to Golgi vesicle-mediated transport; MAPKKK cascade
Disease: Elliptocytosis 2; Pyropoikilocytosis, Hereditary; Spherocytosis, Type 3
Reference #:  P02549 (UniProtKB)
Alt. Names/Synonyms: alpha-I spectrin; EL2; Erythroid alpha-spectrin; HPP; HS3; Spectrin alpha chain, erythrocyte; spectrin, alpha, erythrocytic 1; spectrin, alpha, erythrocytic 1 (elliptocytosis 2); SPH3; SPTA; SPTA1
Gene Symbols: SPTA1
Molecular weight: 280,014 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
Select Structure to View Below

SPTA1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
cytoskeletal reorganization: Y422‑p, Y548‑p, Y1499‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 8 S37‑p EVLTRYQsFKERVAE
0 1 K59‑ac SYHLQVFkRDADDLG
0 1 G251 AAWERLRGLALQRQK
0 3 A259 LALQRQKALSNAANL
0 1 S261 LQRQKALSNAANLQR
0 1 K283‑ac AIQWIKEkEPVLTSE
0 1 S299‑p YGKDLVAsEGLFHSH
0 1 K307 EGLFHSHKGLERNLA
0 1 S317‑p ERNLAVMsDKVKELC
0 1 K329 ELCAKAEKLTLSHPS
0 5 Y370‑p YEKLQATyWYHRFSS
0 1 K389 LSGWMNEKTAAINAD
1 1 Y422‑p HKHEIDSyDDRFQSA
0 1 S507‑p ENEDLGNsLGSAEAL
0 2 S510 DLGNsLGSAEALLQK
1 1 Y548‑p KLIGDDHyDSENIKA
0 4 Y588‑p SLLLQKLyEDSDDLK
0 1 K617 YKDIQNLKSRVQKQQ
0 1 T635‑p KELAVNKtQLENIQK
0 2 S663 DNVTTRLSEVASLWE
0 1 Q700 ENNAEDLQRWLEDVE
0 1 K788 PLATRKKKLLDLLHL
0 2 T802 LQLICRDTEDEEAWI
0 1 T812‑p EEAWIQEtEPSATsT
0 1 S818‑p EtEPSATsTYLGKDL
0 1 S844‑gl VILENIAsHEPRIQE
0 28 Y986‑p EQRVMALyDFQARsP
0 2 S992‑p LyDFQARsPREVTMK
0 4 Y1064‑p QEQIENQyRSLLDRA
0 14 S1167‑p ELNSRWGsLQRLADE
0 1 S1217 DPGSDLFSVQALQRR
0 1 S1250‑gl GETAERLsESHPDAt
0 2 T1257‑p sESHPDAtEDLQRQK
0 1 K1282 QGRTKDRKEsLNEAQ
0 1 S1284‑p RTKDRKEsLNEAQKF
0 1 S1314 SIGGMVSSQELAEDL
0 1 S1363‑p IDSGHHAsPEIEKKL
0 1 S1424‑p SLRSDDKssLDsLEA
0 1 S1425‑p LRSDDKssLDsLEAL
0 3 S1428‑p DDKssLDsLEALMKK
1 1 Y1499‑p ERTKLGDyANLKQFY
0 7 Y1538‑p ATNIQRKyLKHQTFA
0 1 K1579‑ac DGNEEAMkEQLEQLk
0 1 K1586‑ac kEQLEQLkEHWDHLL
0 1 A1640 KDQARDLASAGNLLK
0 1 K1647 ASAGNLLKKHQLLER
0 1 S1738‑gl EKLIRVSsQDYGRDL
0 1 K1803‑ub QFVEHWEkLKELAKA
0 1 S1901‑p SQNKEISsKIEALNE
0 1 T1910‑p IEALNEKtPsLAKAI
0 1 S1912‑p ALNEKtPsLAKAIAA
0 1 S1976‑p KQDTLDAsLQSFQQE
0 2 K2051‑ac LFVEFAHkASALNNW
0 1 K2132 EVLERTWKHLSDIIE
0 1 K2200‑ac ESQLEANkRKQKEIQ
0 1 K2202 QLEANkRKQKEIQAM
0 1 K2210 QKEIQAMKRQLTKIV
0 1 S2269‑p AKDIKGVsEETLKEF
0 1 K2274 GVsEETLKEFSTIYK
0 1 K2281 KEFSTIYKHFDENLT
0 1 K2321 EHEPKFEKFLDAVDP
0 41 Y2333‑p VDPGRKGyVSLEDYT
0 2 S2335 PGRKGyVSLEDYTAF
0 1 S2405‑p PRGRSHLsGyDYVGF
0 1 Y2407‑p GRSHLsGyDYVGFTN
  SPTA1 iso2  
S37 EVLTRYQSFKERVAE
K59 SYHLQVFKRDADDLG
G251 AAWERLRGLALQRQK
A259 LALQRQKALSNAANL
S261 LQRQKALSNAANLQR
K283 AIQWIKEKEPVLTSE
S299 YGKDLVASEGLFHSH
K307 EGLFHSHKGLERNLA
S317 ERNLAVMSDKVKELC
K329 ELCAKAEKLTLSHPS
Y370 YEKLQATYWYHRFSS
K389 LSGWMNEKTAAINAD
Y422 HKHEIDSYDDRFQSA
S507 ENEDLGNSLGSAEAL
S510 DLGNSLGSAEALLQK
Y548 KLIGDDHYDSENIKA
Y588 SLLLQKLYEDSDDLK
K617 YKDIQNLKSRVQKQQ
T635 KELAVNKTQLENIQK
S663 DNVTTRLSEVASLWE
Q700 ENNAEDLQRWLEDVE
K788 PLATRKKKLLDLLHL
T802 LQLICRDTEDEEAWI
T812 EEAWIQETEPSATST
S818 ETEPSATSTYLGKDL
S844 VILENIASHEPRIQE
Y986 EQRVMALYDFQARSP
S992 LYDFQARSPREVTMK
Y1064 QEQIENQYRSLLDRA
S1167 ELNSRWGSLQRLADE
S1217 DPGSDLFSVQALQRR
S1250 GETAERLSESHPDAT
T1257 SESHPDATEDLQRQK
K1282 QGRTKDRKESLNEAQ
S1284 RTKDRKESLNEAQKF
S1314 SIGGMVSSQELAEDL
S1363 IDSGHHASPEIEKKL
S1424 SLRSDDKSSLDSLEA
S1425 LRSDDKSSLDSLEAL
S1428 DDKSSLDSLEALMKK
Y1499 ERTKLGDYANLKQFY
Y1538 ATNIQRKYLKHQTFA
K1579 DGNEEAMKEQLEQLK
K1586 KEQLEQLKEHWDHLL
A1640 KDQARDLASAGNLLK
K1647 ASAGNLLKKHQLLER
S1738 EKLIRVSSQDYGRDL
K1803 QFVEHWEKLKELAKA
S1898 SQNKEISSKIEALNE
T1907 IEALNEKTPSLAKAI
S1909 ALNEKTPSLAKAIAA
S1973 KQDTLDASLQSFQQE
K2048 LFVEFAHKASALNNW
K2129 EVLERTWKHLSDIIE
K2197 ESQLEANKRKQKEIQ
K2199 QLEANKRKQKEIQAM
K2207 QKEIQAMKRQLTKIV
S2266 AKDIKGVSEETLKEF
K2271 GVSEETLKEFSTIYK
K2278 KEFSTIYKHFDENLT
K2318 EHEPKFEKFLDAVDP
Y2330 VDPGRKGYVSLEDYT
S2332 PGRKGYVSLEDYTAF
S2402 PRGRSHLSGYDYVGF
Y2404 GRSHLSGYDYVGFTN
  mouse

 
R36 EVLNQYQRFKDRVAE
R58 SYHYQVFRRDADDLE
S249‑p AAWDRLWsLALKRRE
S257‑p LALKRREsLsNAADL
S259‑p LKRREsLsNAADLQR
K281 AIQWMEEKEPQLTSE
S297 YGKDLVSSEALFHNH
K305 EALFHNHKRLERNLA
D315 ERNLAVMDDKVKELC
K327 ELCAKADKLMISHSA
Y368 YAKLKASYGYHRFLS
K387‑ac LSGWMKEkTALINAD
Y420 HKHEIDSYDDRFQSA
S505 ENEDLGNSVGsVEAL
S508‑p DLGNSVGsVEALLQK
Y546 KLIDNDHYDSENIAA
Y586 SQLLQQLYQDSDDLK
K615‑ub YKDVQNLkSRVQKQQ
I633 EELAVNEIMLNNLEK
S661‑p EAVAARLsEVANLWK
K698‑ub ENNAEDLkRWLEEVE
K786 PLAIRKKKLIDLLKL
S800‑p LQQICRDsEDEEAWI
T810 EEAWIQETEPSAAST
S816 ETEPSAASTHLGKDL
S842 VILADIASHEPRIQV
Y984 EARVIALYDFEARSR
S990 LYDFEARSRREVSMK
Y1062 QQQVETLYHSLLDRA
S1165‑p ELNTRWNsLKRLADE
S1215 DPGSDLLSVQALQRQ
C1248 GETAERLCESHPDAT
T1255 CESHPDATEDLQKQR
K1280‑ac QGLTSDRkESLNEAH
S1282 LTSDRkESLNEAHKF
S1312 TIGGVISSPELAEDL
R1361 IDSGHRNRREIDNTL
D1422 SLRSDDRDHLNsLQA
H1423 LRSDDRDHLNsLQAL
S1426‑p DDRDHLNsLQALMKK
Y1497 ELGKLGDYADLKQFY
Y1536 PTNIQRKYLKHQAFE
Q1577 DGDEENMQEQLDKLK
K1584 QEQLDKLKENWDYLL
T1638‑p KDQARDLtSAGNLLk
K1645‑ub tSAGNLLkKHQLLEA
S1736 EKLLRVSSQDYGRDL
K1801 QFVQHWEKLKELAKT
T1897 QNKDKISTKIQVLNE
T1906 IQVLNEKTASLAKAL
S1908 VLNEKTASLAKALAA
S1972 KHDTLDASLQSFQQE
K2047 LFMEFAHKASAFNNW
N2128 DVLGRIWNHLPDIIK
K2196 ESQLEANKRkQKEIQ
K2198‑m1 QLEANKRkQKEIQAM
K2206‑m1 QKEIQAMkRHLTKIE
S2265 AKDTIGVSEETLkEF
K2270‑ub GVSEETLkEFSTTYk
K2277‑ub kEFSTTYkHFDENLT
K2317‑ub EPEPKFEkFLNAVDP
Y2329 VDPGRKGYVsLEDYT
S2331‑p PGRKGYVsLEDYTSF
A2401 PRGRSQPAGYDYVGF
Y2403 GRSQPAGYDYVGFTN
  rat

 
R36 EVLDQYQRFKERVAE
R58 SYHYQVFRRDADDLE
S249 AAWDRLWSLALKRRE
S257‑p LALKRREsLSNAADL
S259 LKRREsLSNAADLQR
K281 AIQWMEEKEPLLTSE
S297 YGKDLVSSEALFHSH
K305‑ac EALFHSHkRLERNLA
D315 ERNLAVMDDKVKELC
K327‑ac ELCAKADkLMVSHSA
Y368 YAKLKASYGYHRFLS
K387 LTGWMEEKTALINAD
Y420 HKHEIDSYDDRFQTA
S505 ENEDLGNSVGsVEAL
S508‑p DLGNSVGsVEALLQK
Y546 KLIDNDHYDSENIAA
Y586 SQLLQQLYQDSDDLK
K615 YKDVQNLKSRVQKQQ
I633 EELAANEIMLNNLER
S661 DAVAARMSEVANLWK
K698 ENNAEDLKRWLEEVE
K786‑ac PLATRKKkLIDLLKL
S800‑p LQQICRDsEDEEAWI
T810 EEAWIQETEPSAAST
S816 ETEPSAASTHLGKDL
S842 VILADIASHEPRIQT
Y984 EARVIALYDFEARSR
S990 LYDFEARSRREVSMK
Y1062 QEQIETLYHSLLDRA
S1165‑p ELNTRWSsLKRLADE
S1215‑p DPGSDLLsVQALQRQ
C1248 GETAERLCESHPDAT
T1255 CESHPDATEDLQKQR
K1280 QGLTSDRKESLNEAH
S1282 LTSDRKESLNEAHKF
S1312‑p AIGGVISsPELAEDL
S1361 IDRGHRNSHEIETTL
D1422 SLRSDDRDHLNSLQA
H1423 LRSDDRDHLNSLQAL
S1426 DDRDHLNSLQALMKK
Y1497 ELGKLGDYADLKQFY
Y1537 TNIQQRKYLKHQAFE
Q1578 DGDEENMQEQLDKLK
K1585 QEQLDKLKENWDYLL
T1639 KDQARDLTSAGNLLK
K1646 TSAGNLLKKHQLLEA
S1737 EKLLRVSSQDCGRDL
K1802 QFVQHWEKLKELAKT
T1898 QNKDKISTKIEVLNE
T1907 IEVLNEKTASLTKAL
S1909 VLNEKTASLTKALAA
S1973 KQDTLDASLQSFQQE
K2048 LFMEFAHKASAFNNW
K2129‑ac DVLGRIWkHLPEIIK
K2197 ESQLEANKRKQKEIQ
K2199 QLEANKRKQKEIQAM
K2207 QKEIQAMKRHLTKIE
S2266‑p AKDTIGVsEETLKEF
K2271 GVsEETLKEFSTTYK
K2278 KEFSTTYKHFDENLT
K2318 EPEPKFEKFLNAVDP
Y2330 VDPGRKGYVsLEDYT
S2332‑p PGRKGYVsLEDYTSF
A2402 PRGRSQPAGYDYVGF
Y2404 GRSQPAGYDYVGFTN
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