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Protein Page:
MASP2 (human)

Overview
MASP2 Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. Defects in MASP2 are the cause of MASP2 deficiency (MASPD). MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.21.104; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p36.3-p36.2
Cellular Component: extracellular region; extracellular space
Molecular Function: calcium-dependent protein binding; complement component C4b binding; peptidase activity; protein binding; serine-type endopeptidase activity
Biological Process: complement activation; complement activation, lectin pathway
Disease: Masp2 Deficiency
Reference #:  O00187 (UniProtKB)
Alt. Names/Synonyms: mannan-binding lectin serine peptidase 2; Mannan-binding lectin serine protease 2; Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain; Mannose-binding protein-associated serine protease 2; MAP19; MASP-2; MASP1P1; MASP2; MBL-associated plasma protein of 19 kD; MBL-associated serine protease 2; small MBL-associated protein; sMAP
Gene Symbols: MASP2
Molecular weight: 75,702 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
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MASP2

Protein Structure Not Found.
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