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Protein Page:
MASP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MASP2 Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. Defects in MASP2 are the cause of MASP2 deficiency (MASPD). MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Protease; EC 3.4.21.104; Secreted
Chromosomal Location of Human Ortholog: 1p36.3-p36.2
Cellular Component: extracellular region
Molecular Function: calcium-dependent protein binding; complement component C4b binding; peptidase activity; protein binding; serine-type endopeptidase activity
Biological Process: complement activation; complement activation, lectin pathway
Disease: Masp2 Deficiency
Reference #:  O00187 (UniProtKB)
Alt. Names/Synonyms: mannan-binding lectin serine peptidase 2; Mannan-binding lectin serine protease 2; Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain; Mannose-binding protein-associated serine protease 2; MAP19; MASP-2; MASP1P1; MASP2; MBL-associated plasma protein of 19 kD; MBL-associated serine protease 2; small MBL-associated protein; sMAP
Gene Symbols: MASP2
Molecular weight: 75,702 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
Select Structure to View Below

MASP2

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 E38 ASPGFPGEYANDQER
0 1 T250‑p YDFLKIQtDREEHGP
0 1 T262‑p HGPFCGKtLPHRIET
0 1 S325 YILKDSFSIFCETGY
0 1 S353 AVCQKDGSWDRPMPA
0 1 Y388‑p TGPGVTTyKAVIQyS
0 1 Y394‑p TyKAVIQySCEETFy
0 1 Y401‑p ySCEETFyTMKVNDG
0 1 T549‑p VVINSNItPICLPRK
0 1 R578 SGWGLTQRGFLARNL
0 1 Y587‑p FLARNLMyVDIPIVD
0 1 T599‑p IVDHQKCtAAyEKPP
0 1 Y602‑p HQKCtAAyEKPPYPR
0 1 K626 AGLESGGKDSCRGDS
  mouse

 
K38‑ub VSPGFPEkYADHQDR
T250 YDSLKIQTDKGEHGP
T262 HGPFCGKTLPPRIET
S325‑p YVLKDRFsVFCKTGF
S353‑p AVCQKDGsWDRPMPE
Y388 TGPEVTTYKAVIQYS
Y394 TYKAVIQYSCEETFY
Y401 YSCEETFYTMSSNGK
M549 VTINGSIMPVCLPRK
K578‑ub AGWGLTQkGLLARNL
F587 LLARNLMFVDIPIAD
T599 IADHQKCTAVYEKLY
Y602 HQKCTAVYEKLYPGV
K625‑ac AGLETGGkDSCRGDS
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