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BAD
a proapoptotic member of the Bcl-2 family. Displaces Bax from binding to Bcl-2 and Bcl-xL, resulting in cell death. Survival factors such as IL-3 can inhibit the apoptotic activity of Bad inducing the phosphorylation of Bad by Akt and p90RSK. 14-3-3 proteins bind phosphorylated Bad, inhibiting its binding to Bcl-2 and Bcl-xL. Phosphorylation by mitochondria-anchored PKA in the BH3 domain can block the dimerization of Bad and Bcl-xL. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis |
| Chromosomal Location of Human Ortholog: 11q13.1 |
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Cellular Component: cytosol; mitochondrial outer membrane; mitochondrion
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Molecular Function: caspase activator activity; lipid binding; phospholipid binding; protein binding; protein kinase binding
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Biological Process: ADP metabolic process; apoptosis; ATP metabolic process; caspase activation; glucose homeostasis; negative regulation of cytolysis; pore complex biogenesis; positive regulation of apoptosis; positive regulation of autophagy; positive regulation of caspase activity; positive regulation of epithelial cell proliferation; positive regulation of glucokinase activity; positive regulation of insulin secretion; positive regulation of proteolysis; protein insertion into mitochondrial membrane during induction of apoptosis; regulation of mitochondrial membrane permeability
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Reference #:
Q92934
(UniProtKB)
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Alt. Names/Synonyms: BAD; BBC2; BBC6; Bcl-2-binding component 6; Bcl-2-like protein 8; BCL-X/BCL-2 binding protein; Bcl-XL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death; BCL2-antagonist of cell death protein; BCL2-associated agonist of cell death; BCL2-binding component 6; BCL2-binding protein; Bcl2-L-8; BCL2L8
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Gene Symbols: BAD
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Molecular weight:
18,392 Da
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Basal Isoelectric point:
6.6
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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ErbB/HER Signaling
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Growth And Differentiation Control by MAPKs
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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Mitochondrial Control of Apoptosis
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PI3K/Akt Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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