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BMF
May play a role in apoptosis. Isoform 1 seems to be the main initiator. Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2. Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Belongs to the Bcl-2 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Cytoskeletal |
| Chromosomal Location of Human Ortholog: 2|2 E5 |
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Cellular Component: acrosome; actin cytoskeleton; cytoplasm; myosin complex
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Molecular Function: protein binding
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Biological Process: anoikis; cellular response to starvation; negative regulation of autophagy; positive regulation of apoptosis; positive regulation of protein homooligomerization
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Reference #:
Q91ZE9
(UniProtKB)
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Alt. Names/Synonyms: AW260063; AW411872; bcl-2-modifying factor; Bcl2 modifying factor; Bmf; OTTMUSP00000016372
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Gene Symbols: Bmf
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Molecular weight:
20,682 Da
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Basal Isoelectric point:
4.93
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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