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Protein Page:
SHP-2 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SHP-2 a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q24
Cellular Component: cytoplasm; cytosol; mitochondrion; nucleus; protein complex
Molecular Function: D1 dopamine receptor binding; insulin receptor binding; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; peptide hormone receptor binding; phospholipase binding; phosphoprotein phosphatase activity; protein binding; protein domain specific binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; SH3/SH2 adaptor activity
Biological Process: abortive mitotic cell cycle; activation of MAPK activity; axon guidance; Bergmann glial cell differentiation; blood coagulation; brain development; cerebellar cortex formation; cytokine and chemokine mediated signaling pathway; DNA damage checkpoint; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; genitalia development; glucose homeostasis; heart development; homeostasis of number of cells within a tissue; hormone metabolic process; hormone-mediated signaling; innate immune response; inner ear development; insulin receptor signaling pathway; integrin-mediated signaling pathway; leukocyte migration; microvillus organization and biogenesis; multicellular organism growth; negative regulation of cell adhesion mediated by integrin; negative regulation of cortisol secretion; negative regulation of growth hormone secretion; negative regulation of insulin secretion; nerve growth factor receptor signaling pathway; organ growth; phosphoinositide-mediated signaling; platelet activation; platelet formation; platelet-derived growth factor receptor signaling pathway; positive regulation of hormone secretion; positive regulation of mitotic cell cycle; regulation of cell adhesion mediated by integrin; regulation of multicellular organism growth; regulation of protein complex assembly; regulation of protein export from nucleus; reproductive process in a multicellular organism; T cell costimulation; triacylglycerol metabolic process
Disease: Juvenile Myelomonocytic Leukemia; Leopard Syndrome 1; Metachondromatosis; Noonan Syndrome 1
Reference #:  Q06124 (UniProtKB)
Alt. Names/Synonyms: BPTP3; CFC; MGC14433; NS1; protein tyrosine phosphatase, non-receptor type 11; protein tyrosine phosphatase-2; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTN11; PTP-1D; PTP-2C; PTP2C; PTPN11; SH-PTP2; SH-PTP3; SHP-2; Shp2; SHPTP2; Tyrosine-protein phosphatase non-receptor type 11
Gene Symbols: PTPN11
Molecular weight: 68,436 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  IL6 Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SHP-2

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: Y546‑p
cell motility, altered: Y546‑p, Y584‑p
cytoskeletal reorganization: Y546‑p
transcription, altered: Y546‑p
enzymatic activity, induced: Y546‑p, Y584‑p
molecular association, regulation: Y546‑p, Y584‑p
phosphorylation: Y584‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S28‑p LTRGVDGsFLARPsK
0 1 S34‑p GsFLARPsKsNPGDF
0 2 S36‑p FLARPsKsNPGDFTL
0 3 T59‑p THIKIQNtGDyyDLy
1 2085 Y62‑p KIQNtGDyyDLyGGE
1 82 Y63‑p IQNtGDyyDLyGGEK
0 14 Y66‑p tGDyyDLyGGEKFAT
1 0 T73 yGGEKFATLAELVQy
0 1 Y80‑p TLAELVQyYMEHHGQ
0 1 K91 HHGQLKEKNGDVIEL
0 1 K120 FHGHLSGKEAEKLLT
0 1 K124 LSGKEAEKLLTEKGK
0 1 K131 KLLTEKGKHGSFLVR
0 3 T153‑p DFVLSVRtGDDKGES
0 1 S165‑p GESNDGKsKVTHVMI
0 1 K178‑ac MIRCQELkyDVGGGE
0 3 Y179‑p IRCQELkyDVGGGER
1 0 S189 GGGERFDSLTDLVEH
0 4 K198‑ac TDLVEHYkKNPMVET
0 8 Y263‑p QQECKLLysRKEGQR
0 1 S264‑p QECKLLysRKEGQRQ
0 1 K274‑ac EGQRQENkNkNRykN
0 1 K276‑ac QRQENkNkNRykNIL
1 48 Y279‑p ENkNkNRykNILPFD
0 2 K280‑ac NkNkNRykNILPFDH
0 20 S302‑p GDPNEPVsDyINANI
2 53 Y304‑p PNEPVsDyINANIIM
1 0 Y327 NSKPKKSYIATQGCL
0 1 T415‑p QALLQGNtERTVWQY
0 3 K486‑ac LIDIIREkGVDCDID
1 39 Y515‑p MVQTEAQyRFIyMAV
0 16 Y519‑p EAQyRFIyMAVQHYI
25 421 Y546‑p SKRKGHEytNIKysL
0 28 T547‑p KRKGHEytNIKysLA
0 2 Y551‑p HEytNIKysLADQts
0 1 S552‑p EytNIKysLADQtsG
0 10 T557‑p KysLADQtsGDQsPL
0 1 S558‑p ysLADQtsGDQsPLP
0 14 S562‑p DQtsGDQsPLPPCtP
0 15 T568‑p QsPLPPCtPtPPCAE
0 6 T570‑p PLPPCtPtPPCAEMR
2 11 S580‑p CAEMREDsARVyENV
15 1188 Y584‑p REDsARVyENVGLMQ
1 0 K594 VGLMQQQKsFR____
1 51 S595‑p GLMQQQKsFR_____
  SHP-2 iso2  
S28 LTRGVDGSFLARPSK
S34 GSFLARPSKSNPGDF
S36 FLARPSKSNPGDFTL
T59 THIKIQNTGDYYDLY
Y62 KIQNTGDYYDLYGGE
Y63 IQNTGDYYDLYGGEK
Y66 TGDYYDLYGGEKFAt
T73‑p YGGEKFAtLAELVQY
Y80 tLAELVQYYMEHHGQ
K91 HHGQLKEKNGDVIEL
K120 FHGHLSGKEAEKLLT
K124 LSGKEAEKLLTEKGK
K131 KLLTEKGKHGSFLVR
T153 DFVLSVRTGDDKGES
S165 GESNDGKSKVTHVMI
K178 MIRCQELKYDVGGGE
Y179 IRCQELKYDVGGGER
S189‑p GGGERFDsLTDLVEH
K198 TDLVEHYKKNPMVET
Y263 QQECKLLYSRKEGQR
S264 QECKLLYSRKEGQRQ
K274 EGQRQENKNKNRYKN
K276 QRQENKNKNRYKNIL
Y279 ENKNKNRYKNILPFD
K280 NKNKNRYKNILPFDH
S302 GDPNEPVSDYINANI
Y304 PNEPVSDYINANIIM
Y327 NSKPKKSYIATQGCL
T411 SKVGQGNTERTVWQY
K482 LIDIIREKGVDCDID
Y511‑p MVQTEAQyRFIYMAV
Y515 EAQyRFIYMAVQHYI
Y542‑p SKRKGHEyTNIKYSL
T543 KRKGHEyTNIKYSLA
Y547 HEyTNIKYSLADQTS
S548 EyTNIKYSLADQTSG
T553 KYSLADQTSGDQSPL
S554 YSLADQTSGDQSPLP
S558 DQTSGDQSPLPPCTP
T564 QSPLPPCTPTPPCAE
T566 PLPPCTPTPPCAEMR
S576 CAEMREDSARVyENV
Y580‑p REDSARVyENVGLMQ
K590‑sm VGLMQQQkSFR____
S591 GLMQQQkSFR_____
  mouse

 
S28 LTRGVDGSFLARPSK
S34 GSFLARPSKsNPGDF
S36‑p FLARPSKsNPGDFTL
T59 THIKIQNTGDyyDLy
Y62‑p KIQNTGDyyDLyGGE
Y63‑p IQNTGDyyDLyGGEK
Y66‑p TGDyyDLyGGEKFAT
T73 yGGEKFATLAELVQY
Y80 TLAELVQYYMEHHGQ
K91‑ub HHGQLKEkNGDVIEL
K120 FHGHLSGKEAEKLLT
K124 LSGKEAEKLLTEKGK
K131 KLLTEKGKHGSFLVR
T153 DFVLSVRTGDDKGES
S165 GESNDGKSKVTHVMI
K178 MIRCQELKYDVGGGE
Y179 IRCQELKYDVGGGER
S189 GGGERFDSLTDLVEH
K198‑ac TDLVEHYkKNPMVET
Y263 QQECKLLYSRKEGQR
S264 QECKLLYSRKEGQRQ
K274 EGQRQENKNKNRyKN
K276 QRQENKNKNRyKNIL
Y279‑p ENKNKNRyKNILPFD
K280 NKNKNRyKNILPFDH
S302 GDPNEPVSDyINANI
Y304‑p PNEPVSDyINANIIM
Y327‑p NSKPKKSyIATQGCL
T415 QALLQGNTERTVWQY
K486 LIDIIREKGVDCDID
Y515‑p MVQTEAQyRFIYMAV
Y519 EAQyRFIYMAVQHYI
Y546‑p SKRKGHEytNIKYSL
T547‑p KRKGHEytNIKYSLV
Y551 HEytNIKYSLVDQTS
S552 EytNIKYSLVDQTSG
T557 KYSLVDQTSGDQsPL
S558 YSLVDQTSGDQsPLP
S562‑p DQTSGDQsPLPPCTP
T568 QsPLPPCTPTPPCAE
T570 PLPPCTPTPPCAEMR
S580‑p CAEMREDsARVyENV
Y584‑p REDsARVyENVGLMQ
R594 VGLMQQQRSFR____
S595 GLMQQQRSFR_____
3751 : Phospho-SHP-2 (Tyr542) Antibody
3703 : Phospho-SHP-2 (Tyr580) Antibody
5431 : Phospho-SHP-2 (Tyr580) (D66F10) Rabbit mAb
13328 : Phospho-SHP-2 (Tyr580) (D66F10) Rabbit mAb (PE Conjugate)
  rat

 
S28 LTRGVDGSFLARPSK
S34 GSFLARPSKSNPGDF
S36 FLARPSKSNPGDFTL
T59 THIKIQNTGDyyDLY
Y62‑p KIQNTGDyyDLYGGE
Y63‑p IQNTGDyyDLYGGEK
Y66 TGDyyDLYGGEKFAT
T73 YGGEKFATLAELVQY
Y80 TLAELVQYYMEHHGQ
K91 HHGQLKEKNGDVIEL
K120‑ac FHGHLSGkEAEkLLT
K124‑ac LSGkEAEkLLTEKGk
K131‑ac kLLTEKGkHGSFLVR
T153 DFVLSVRTGDDKGES
S165 GESNDSKSKVTHVMI
K178 MIRCQELKYDVGGGE
Y179 IRCQELKYDVGGGER
S189 GGGERFDSLTDLVEH
K198‑ac TDLVEHYkKNPMVET
Y263 QQECKLLYSRKEGQR
S264 QECKLLYSRKEGQRQ
K274 EGQRQENKNKNRYkN
K276 QRQENKNKNRYkNIL
Y279 ENKNKNRYkNILPFD
K280‑ac NKNKNRYkNILPFDH
S302 GDPNEPVSDYINANI
Y304 PNEPVSDYINANIIM
Y327 NSKPKKSYIATQGCL
T415 QALLQGNTERTVWQY
K486‑ac LIDIIREkGVDCDID
Y515 MVQTEAQYRFIYMAV
Y519 EAQYRFIYMAVQHYI
Y546‑p SKRKGHEyTNIKYSL
T547 KRKGHEyTNIKYSLV
Y551 HEyTNIKYSLVDQTS
S552 EyTNIKYSLVDQTSG
T557 KYSLVDQTSGDQsPL
S558 YSLVDQTSGDQsPLP
S562‑p DQTSGDQsPLPPCTP
T568 QsPLPPCTPtPPCAE
T570‑p PLPPCTPtPPCAEMR
S580‑p CAEMREDsARVyENV
Y584‑p REDsARVyENVGLMQ
R594 VGLMQQQRSFR____
S595 GLMQQQRSFR_____
3703 : Phospho-SHP-2 (Tyr580) Antibody
5431 : Phospho-SHP-2 (Tyr580) (D66F10) Rabbit mAb
13328 : Phospho-SHP-2 (Tyr580) (D66F10) Rabbit mAb (PE Conjugate)
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