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Protein Page:
STAT5B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAT5B transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases triggered by cytokines including IL2, IL3, GM-CSF, and various growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: chromatin binding; glucocorticoid receptor binding; protein binding; protein dimerization activity; protein phosphatase binding; signal transducer activity; transcription factor activity
Biological Process: 2-oxoglutarate metabolic process; acute-phase response; allantoin metabolic process; cellular response to hormone stimulus; citrate metabolic process; creatine metabolic process; creatinine metabolic process; development of secondary female sexual characteristics; development of secondary male sexual characteristics; fatty acid metabolic process; female pregnancy; isoleucine metabolic process; JAK-STAT cascade; lactation; liver development; luteinization; natural killer cell differentiation; negative regulation of apoptosis; negative regulation of erythrocyte differentiation; oxaloacetate metabolic process; Peyer's patch development; positive regulation of activated T cell proliferation; positive regulation of B cell differentiation; positive regulation of cell motility; positive regulation of gamma-delta T cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-2 biosynthetic process; positive regulation of mitotic cell cycle; positive regulation of multicellular organism growth; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; progesterone metabolic process; regulation of epithelial cell differentiation; regulation of multicellular organism growth; regulation of steroid metabolic process; regulation of transcription from RNA polymerase II promoter; response to estradiol stimulus; response to ethanol; response to hypoxia; response to lipopolysaccharide; sequestering of lipid; succinate metabolic process; T cell differentiation in the thymus; T cell homeostasis; taurine metabolic process; transcription from RNA polymerase II promoter; valine metabolic process
Disease: Growth Hormone Insensitivity With Immunodeficiency
Reference #:  P51692 (UniProtKB)
Alt. Names/Synonyms: Signal transducer and activator of transcription 5B; STA5B; STAT5; STAT5B; transcription factor STAT5B
Gene Symbols: STAT5B
Molecular weight: 89,866 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT5B

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: Y699‑p
transcription, altered: Y699‑p, S731‑p, Y740‑p, Y743‑p
transcription, induced: S193‑p, Y699‑p, Y725‑p
transcription, inhibited: Y740‑p, Y743‑p
activity, induced: Y699‑p, S731‑p
activity, inhibited: Y740‑p, Y743‑p
molecular association, regulation: S193‑p, Y699‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 263 Y90‑p LKIKLGHyAtQLQNT
0 5 T92‑p IKLGHyAtQLQNTYD
0 200 Y114‑p RCIRHILyNEQRLVR
0 11 S128‑p REANNGSsPAGsLAD
0 3 S132‑p NGSsPAGsLADAMSQ
0 1 K164‑ub DTENELKkLQQTQEY
0 2 Y171 kLQQTQEYFIIQYQE
1 16 S193‑p FGPLAQLsPQERLSR
0 1 K232‑ub YRVELAEkHQKTLQL
0 1 K242‑ub KTLQLLRkQQTIILD
0 1 K380‑ub IISEQQAkSLLkNEN
0 3 K384‑ac QQAkSLLkNENTRND
0 2 Y392‑p NENTRNDySGEILNN
0 3 Y665‑p DRLGDLNyLIyVFPD
0 7 Y668‑p GDLNyLIyVFPDRPK
1 0 Y679 DRPKDEVYSKyytPV
0 5 Y682‑p KDEVYSKyytPVPCE
0 50 Y683‑p DEVYSKyytPVPCES
0 3 T684‑p EVYSKyytPVPCESA
0 2 T692‑p PVPCESAtAKAVDGy
35 2244 Y699‑p tAKAVDGyVKPQIKQ
3 1 Y725‑p AGGGSATyMDQAPsP
12 0 S731‑p TyMDQAPsPAVCPQA
4 0 Y740‑p AVCPQAHyNMyPQNP
4 0 Y743‑p PQAHyNMyPQNPDSV
0 3 S787‑p QWIPHAQs_______
  mouse

 
Y90 LKIKLGHYATQLQST
T92 IKLGHYATQLQSTYD
Y114‑p RCIRHILyNEQRLVR
S128‑p REANNGSsPAGsLAD
S132‑p NGSsPAGsLADAMSQ
K164 DTENELKKLQQTQEy
Y171‑p KLQQTQEyFIIQYQE
N193 FAQLGQLNPQERMSR
K232 YRVELAEKHQKTLQL
K242 KTLQLLRKQQTIILD
K380 IISEQQAKSLLKNEN
K384 QQAKSLLKNENTRND
Y392 NENTRNDYSGEILNN
Y665 DRLGDLNYLIYVFPD
Y668 GDLNYLIYVFPDRPK
Y679 DRPKDEVYSKYYTPV
Y682 KDEVYSKYYTPVPCE
Y683 DEVYSKYYTPVPCEP
T684 EVYSKYYTPVPCEPA
T692 PVPCEPATAKAADGy
Y699‑p TAKAADGyVKPQIKQ
Y724 DAGSGATYMDQAPsP
S730‑p TYMDQAPsPVVCPQA
Y739 VVCPQAHYNMYPPNP
Y742 PQAHYNMYPPNPDSV
S786 QWIPHAQS_______
3939 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4322 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb
5387 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (PE Conjugate)
9314 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb
9351 : Phospho-Stat5 (Tyr694) Antibody
9356 : Phospho-Stat5 (Tyr694) (14H2) Mouse mAb
9359 : Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb
9365 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
14603 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb (PE Conjugate)
  rat

 
Y90‑p LKIKLGHyATQLQNT
T92 IKLGHyATQLQNTYD
Y114 RCIRHILYNEQRLVR
S128‑p REANNGSsPAGSLAD
S132 NGSsPAGSLADAMSQ
K164 DTESELKKLQQTQEY
Y171 KLQQTQEYFIIQYQE
N193 FAQLAQLNPQERMSR
K232 YRVELAEKHQKTLQL
K242 KTLQLLRKQQTIILD
K380 IISEQQAKSLLKNEN
K384 QQAKSLLKNENTRND
Y392 NENTRNDYSGEILNN
Y665 DRLGDLNYLIYVFPD
Y668 GDLNYLIYVFPDRPK
Y679‑p DRPKDEVySKYYTPV
Y682 KDEVySKYYTPVPCE
Y683 DEVySKYYTPVPCER
T684 EVySKYYTPVPCERA
T692 PVPCERATAKAADGy
Y699‑p TAKAADGyVKPQIKQ
Y724‑p DAGSGATyMDQAPsP
S730‑p TyMDQAPsPVVCPQA
Y739 VVCPQAHYNMYPQNP
Y742 PQAHYNMYPQNPDSV
S786 QWIPHAQS_______
3939 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4322 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb
5387 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (PE Conjugate)
9314 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb
9351 : Phospho-Stat5 (Tyr694) Antibody
9356 : Phospho-Stat5 (Tyr694) (14H2) Mouse mAb
9359 : Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb
9365 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
14603 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb (PE Conjugate)
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