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Protein Page:
Kv7.5 (human)

Overview
Kv7.5 Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6q14
Cellular Component: clathrin coat; plasma membrane
Molecular Function: delayed rectifier potassium channel activity; inward rectifier potassium channel activity; protein binding; voltage-gated potassium channel activity
Biological Process: synaptic transmission
Reference #:  Q9NR82 (UniProtKB)
Alt. Names/Synonyms: KCNQ5; KQT-like 5; Kv7.5; potassium channel protein; Potassium channel subunit alpha KvLQT5; Potassium voltage-gated channel subfamily KQT member 5; potassium voltage-gated channel, KQT-like subfamily, member 5; Voltage-gated potassium channel subunit Kv7.5
Gene Symbols: KCNQ5
Molecular weight: 102,179 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
Select Structure to View Below

Kv7.5

Protein Structure Not Found.


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