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Protein Page:
Kv7.5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Kv7.5 Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q14
Cellular Component: clathrin coat; plasma membrane
Molecular Function: delayed rectifier potassium channel activity; inward rectifier potassium channel activity; protein binding; voltage-gated potassium channel activity
Biological Process: synaptic transmission
Reference #:  Q9NR82 (UniProtKB)
Alt. Names/Synonyms: KCNQ5; KQT-like 5; Kv7.5; potassium channel protein; Potassium channel subunit alpha KvLQT5; Potassium voltage-gated channel subfamily KQT member 5; potassium voltage-gated channel, KQT-like subfamily, member 5; Voltage-gated potassium channel subunit Kv7.5
Gene Symbols: KCNQ5
Molecular weight: 102,179 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
Select Structure to View Below

Kv7.5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 T67‑p LLGTRAAtLGGGGGG
0 4 S78‑p GGGGLREsRRGKQGA
0 2 S88 GKQGARMSLLGKPLS
0 1 K92 ARMSLLGKPLSyTSS
0 2 Y96‑p LLGKPLSyTSSQSCR
0 2 S263‑p GSVVYAHsKELITAW
0 1 K361 VQEQHRQKHFEKRRN
0 1 K365 HRQKHFEKRRNPAAN
0 1 - gap
0 2 - gap
0 2 - gap
0 1 E412 PTKKEQGEASSSQKL
0 4 S447‑p ASVGDRRsPSTDITA
0 1 S449 VGDRRsPSTDITAEG
0 6 S457‑p TDITAEGsPtKVQKS
0 2 T459‑p ITAEGsPtKVQKSWs
0 6 S466‑p tKVQKSWsFNDRTRF
0 2 Y500‑p ALGTDDVyDEKGCQC
0 1 T581‑p ILGKGQItSDKKSRE
0 1 K584 KGQItSDKKSREKIT
0 1 S618‑p KQVQSIEskLDCLLD
0 1 K619‑ub QVQSIEskLDCLLDI
0 1 Y657‑p ECEQTSDyQSPVDSK
0 1 S807‑p KDRSMRKsFDMGGET
0 5 S831‑p KDLGKSLsVQNLIRS
0 1 Y861‑p SRGSQDFyPkWRESK
0 1 K863‑ac GSQDFyPkWRESKLF
0 1 S902‑p EAAFASDsLRTGRSR
  Kv7.5 iso3  
T67 LLGTRAATLGGGGGG
S78 GGGGLRESRRGKQGA
S88 GKQGARMSLLGKPLS
K92 ARMSLLGKPLSYTSS
Y96 LLGKPLSYTSSQSCR
S263 GSVVYAHSKELITAW
K361 VQEQHRQKHFEKRRN
K365 HRQKHFEKRRNPAAN
S411‑p SPTNKFCsNKQKLFR
Y420‑p KQKLFRMytsRKQSQ
T421‑p QKLFRMytsRKQSQK
S422‑p KLFRMytsRKQSQKL
S457 ASVGDRRSPSTDITA
S459 VGDRRSPSTDITAEG
S467 TDITAEGSPTKVQKS
T469 ITAEGSPTKVQKSWS
S476 TKVQKSWSFNDRTRF
Y510 ALGTDDVYDEKGCQC
T591 ILGKGQITSDKKSRE
K594 KGQITSDKKSREKIT
S628 KQVQSIESKLDCLLD
K629 QVQSIESKLDCLLDI
Y667 ECEQTSDYQSPVDSK
S817 KDRSMRKSFDMGGET
S841 KDLGKSLSVQNLIRS
Y871 SRGSQDFYPKWRESK
K873 GSQDFYPKWRESKLF
S912 EAAFASDSLRTGRSR
  mouse

► Hide Isoforms
 
A68 LLGTRAAALGGGGGG
S79 GGGGLRESRRGKQGA
S89‑p GKQGARMsLLGkPLS
K93‑ub ARMsLLGkPLSYTSS
Y97 LLGkPLSYTSSQSCR
S264‑p GSVVYAHsKELITAW
K362‑ac VQEQHRQkHFEkRRN
K366‑ac HRQkHFEkRRNPAAN
- gap
- gap
- gap
E413 PTKKEQGEASSSQKL
S448‑p ASVGDRRsPsTDITA
S450‑p VGDRRsPsTDITAEG
S458‑p TDITAEGsPtKVQKS
T460‑p ITAEGsPtKVQKSWs
S467‑p tKVQKSWsFNDRTRF
Y501 ALGIDDVYDEKGCQC
T582 ILGKGQMTSDkKSRE
K585‑ac KGQMTSDkKSREKIT
S619 KQVQSIESKLDCLLD
K620 QVQSIESKLDCLLDI
Y658 ECEQTSDYQSPVDSK
S808 KDRSLRKSFDMGGET
S832‑p KDLGKSLsVQNLIRS
Y862 SRGSQDFYPKWRESK
K864 GSQDFYPKWRESKLF
S903 EAAFSSDSLRTGRSR
  Kv7.5 iso2  
A68 LLGTRAAALGGGGGG
S79 GGGGLRESRRGKQGA
S89 GKQGARMSLLGKPLS
K93 ARMSLLGKPLSYTSS
Y97 LLGKPLSYTSSQSCR
S264 GSVVYAHSKELITAW
K362 VQEQHRQKHFEKRRN
K366 HRQKHFEKRRNPAAN
- gap
- gap
- gap
- gap
S439 ASVGDRRSPSTDITA
S441 VGDRRSPSTDITAEG
S449 TDITAEGSPTKVQKS
T451 ITAEGSPTKVQKSWS
S458 TKVQKSWSFNDRTRF
Y492 ALGIDDVYDEKGCQC
T573 ILGKGQMTSDKKSRE
K576 KGQMTSDKKSREKIT
S610 KQVQSIESKLDCLLD
K611 QVQSIESKLDCLLDI
Y649 ECEQTSDYQSPVDSK
S799 KDRSLRKSFDMGGET
S823 KDLGKSLSVQNLIRS
Y853 SRGSQDFYPKWRESK
K855 GSQDFYPKWRESKLF
S894 EAAFSSDSLRTGRSR
  rat

 
A66 LLGTRAAALGGGGGG
S77 GGGGLRESRRGKQGA
S87 GKQGARMSLLGKPLS
K91 ARMSLLGKPLSYTSS
Y95 LLGKPLSYTSSQSCR
S262 GSVVYAHSKELITAW
K360 VQEQHRQKHFEKRRN
K364 HRQKHFEKRRNPAAN
- gap
- gap
- gap
E411 PTKKEQGEAASSQKL
S446‑p ASVGDRRsPSTDITA
S448 VGDRRsPSTDITAEG
S456‑p TDITAEGsPTKVQKS
T458 ITAEGsPTKVQKSWs
S465‑p TKVQKSWsFNDRTRF
Y499 ALGIDDVYDEKGCQC
T580 ILGKGQITSDKKSRE
K583 KGQITSDKKSREKIT
S618 KQVQSIESKLDCLLD
K619 QVQSIESKLDCLLDI
Y657 ECEQTSDYQSPVESK
S807 KDRSLRKSFDMGGET
S831 KDLGKSLSVQNLIRS
Y861 SRGSQDFYPKWRESK
K863 GSQDFYPKWRESKLF
S902 EAAFSSDSLRTGRSR
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