Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
XPA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
XPA Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Interacts with GPN1 and RPA1. Interacts (via N-terminus) with CEP164 upon UV irradiation. Interacts with HERC2. Expressed in various cell lines and in skin fibroblasts. Belongs to the XPA family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 9q22.3
Cellular Component: cytoplasm; DNA replication factor A complex; Golgi apparatus; intercellular bridge; nucleoplasm; nucleus
Molecular Function: damaged DNA binding; protein binding; protein domain specific binding; protein homodimerization activity
Biological Process: base-excision repair; DNA repair; nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, preincision complex stabilization; transcription-coupled nucleotide-excision repair
Disease: Xeroderma Pigmentosum, Complementation Group A
Reference #:  P23025 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein complementing XP-A cells; excision repair-controlling; Xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A; XP1; XPA; XPAC
Gene Symbols: XPA
Molecular weight: 31,368 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

XPA

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
apoptosis, altered: S196‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 L8 MAAADGALPEAAALE
0 1 Y48‑p ARLAARPySATAAAA
0 1 K63‑sm TGGMANVkAAPKIID
0 1 K141‑sm DKHKLITkTEAkQEY
0 1 K145‑sm LITkTEAkQEYLLKD
0 1 K157‑ac LKDCDLEkREPPLKF
1 0 S173‑p VKKNPHHsQWGDMKL
3 3 S196‑p RSLEVWGsQEALEEA
0 1 T239‑p SSVWKREtIVHQHEY
0 3 Y257‑p ENLEDDMyRKTCTMC
  mouse

 
S10‑p TAEEKQTsPEPVAAD
Y50 ARLAARPYPAAAATG
K63 TGGVASVKAAPKMID
K140 DKHKLITKTEAKQEY
K144 LITKTEAKQEYLLKD
K156 LKDCDLEKREPALRF
S172 VKKNPRHSQWGDMKL
S195 RALEVWGSQEALEDA
T238 SSVWKRETTTHQHKY
Y256 ENLEDDMYRKTCTLC
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.