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Protein Page:
EDG-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EDG-1 a G protein-coupled receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Highly expressed in endothelial cells and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. Suggested to be involved in the processes that regulate the migration/differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. S1P-induced endothelial cell migration requires AKT1-mediated phosphorylation of the third intracellular loop. Seems to be coupled to the G(i) subclass of heteromeric G proteins. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p21
Cellular Component: intrinsic to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; G-protein-coupled receptor binding
Biological Process: actin cytoskeleton reorganization; blood vessel maturation; cell adhesion; cell migration; chemotaxis; G-protein coupled receptor protein signaling pathway; lamellipodium biogenesis; regulation of bone mineralization; regulation of bone resorption
Reference #:  P21453 (UniProtKB)
Alt. Names/Synonyms: CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; Endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; FLJ58121; S1P receptor 1; S1P receptor Edg-1; S1P1; S1PR1; Sphingosine 1-phosphate receptor 1; Sphingosine 1-phosphate receptor Edg-1; sphingosine 1-phosphate receptor EDG1; sphingosine-1-phosphate receptor 1
Gene Symbols: S1PR1
Molecular weight: 42,811 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
Select Structure to View Below

EDG-1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
cell motility, altered: T236‑p
cytoskeletal reorganization: T236‑p
receptor internalization, induced: Y143‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T4‑ga ____MGPtsVPLVKA
0 1 S5‑ga ___MGPtsVPLVKAH
0 1 S129‑p GSMFVALsASVFSLL
1 0 Y143‑p LAIAIERyITMLKMK
2 1 T236‑p RTRSRRLtFRKNISK
0 1 K330‑ac IRIMSCCkCPSGDSA
0 1 K341 GDSAGKFKRPIIAGM
1 8 S351‑p IIAGMEFsRsKsDNs
1 4 S353‑p AGMEFsRsKsDNssH
1 3 S355‑p MEFsRsKsDNssHPQ
1 2 S358‑p sRsKsDNssHPQKDE
1 0 S359‑p RsKsDNssHPQKDEG
  mouse

 
T4 ____MVSTSIPEVKA
S5 ___MVSTSIPEVKAL
S129 GSMFVALSASVFSLL
Y143 LAIAIERYITMLKMK
T236‑p RTRSRRLtFRKNISK
K330 IRIVSCCKCPNGDSA
K341‑ub GDSAGKFkRPIIPGM
S351‑p IIPGMEFsRsKsDNs
S353‑p PGMEFsRsKsDNsSH
S355‑p MEFsRsKsDNsSHPQ
S358‑p sRsKsDNsSHPQKDD
S359 RsKsDNsSHPQKDDG
  rat

 
T5 ___MVSSTSIPVVKA
S6 __MVSSTSIPVVKAL
S130 GSMFVALSASVFSLL
Y144 LAIAIERYITMLKMK
T237 RTRSRRLTFRKNISK
K331 IRIISCCKCPNGDSA
K342 GDSAGKFKRPIIPGM
S352‑p IIPGMEFsRsKSDNS
S354‑p PGMEFsRsKSDNSSH
S356 MEFsRsKSDNSSHPQ
S359 sRsKSDNSSHPQKDD
S360 RsKSDNSSHPQKDDG
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