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Protein Page:
WASP (human)

WASP a member of the Wiskott-Aldrich syndrome (WAS) family of proteins. A cytoplasmic protein expressed exclusively in hematopoietic cells. Transduces signals from surface receptors to the actin cytoskeleton. Associates with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Mutated in Wiskott-Aldrich syndrome, a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xp11.4-p11.21
Cellular Component: actin cytoskeleton; cytosol
Molecular Function: GTPase regulator activity; phospholipase binding; protein binding; protein kinase binding; SH3 domain binding
Biological Process: actin polymerization and/or depolymerization; blood coagulation; defense response; epidermis development; immune response; protein complex assembly; regulation of T cell antigen processing and presentation; T cell receptor signaling pathway
Disease: Neutropenia, Severe Congenital, X-linked; Thrombocytopenia 1
Reference #:  P42768 (UniProtKB)
Alt. Names/Synonyms: IMD2; THC; THC1; thrombocytopenia 1 (X-linked); WAS; WASp; Wiskott-Aldrich syndrome (eczema-thrombocytopenia); Wiskott-Aldrich syndrome protein
Gene Symbols: WAS
Molecular weight: 52,913 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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